Possible effects of L-carnosine, aminoguanidine and their combination on experimentally induced- hepatic encephalopathy in rats / (Record no. 78646)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03228cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032626.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201109s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.15.Ph.D.2020.Ah.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelfatah Abdallah Sedik |
| 245 10 - TITLE STATEMENT | |
| Title | Possible effects of L-carnosine, aminoguanidine and their combination on experimentally induced- hepatic encephalopathy in rats / |
| Statement of responsibility, etc. | Ahmed Abdelfatah Abdallah Sedik ; Supervised Nehal Ali Afifi , Amer Ramadan Aly Ayad , Dalia Osama Saleh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التاثيرات المحتملة للكارنوزين والامينوجوانيدين والجمع بينهما على الاعتلال الدماغى الكبدى المستحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Abdelfatah Abdallah Sedik , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 87 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatic encephalopathy (HE) describes the array of neurological alterations that occur during acute or chronic liver injury. Hyperammonemia, oxidative stress and inflammatory injury are the main crucial factors for the pathophysiological changes associated with HE in rats. The present study was designed to evaluate the possible synergistic effect between aminoguanidine (AG; 100 mg/kg; p.o.) and l-carnosine (CAR; 100 mg/kg; p.o.) on HE that was induced by thioacetamide (TAA; 100 mg/kg.i.p) thrice weekly for six consecutive weeks. Twenty-four hours after the last treatment{u037E} behavioral changes, biochemical parameters , histopathological analysis, immunohistochemical and ultrastructural studies were conducted. The obtained results showed that combining AG with CAR improved TAA-induced locomotor impairment and motor incoordination evidenced by; reduced locomotor activity and decline in motor skill performance as well as ameliorated cognitive deficits. Moreover, both drugs restored the levels of serum hepatic enzymes as well as serum and brain levels of ammonia. In addition to, the combination significantly modulated hepatic and brain oxidative stress biomarkers, inflammatory cytokines and cleaved caspase-3 expression. Furthermore, they succeeded to activate nuclear erythroid 2-related factor 2 (Nrf2) expressions, heme oxygenase-1 (HO-1) activity and ameliorate markers of HE including hepatic necrosis and brain astrocyte swelling. This study depicts that combining AG with CAR exerted new intervention for hepatic and brain damage in HE due to their complementary antioxidant, anti-inflammatory effect and hypoammonemic effects via Nrf2/HO-1activator and NO inhibitors |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aminoguanidine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatic encephalopathy (HE) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | L-carnosine |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amer Ramadan Aly Ayad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Osama Saleh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nehal Ali Afifi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.15.Ph.D.2020.Ah.P | 01010110081959000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.15.Ph.D.2020.Ah.P | 01020110081959000 | 22.09.2023 | CD - Rom | 81959.CD |