Synthesis and biological evaluation of certain pyrazole derivatives derived from natural products and other synthetic analogues / (Record no. 78650)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02862cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032626.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201109s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2020.Ah.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abbass Mohamed Abdelrahman Selim |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and biological evaluation of certain pyrazole derivatives derived from natural products and other synthetic analogues / |
| Statement of responsibility, etc. | Ahmed Abbass Mohamed Abdelrahman Selim ; Supervised Fatma Abdelfattah Ragab , Enas Ibrahim Mohamed , Yassin Mohammed Nissan Soliman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد و تقييم بيولوجى لبعض مشتقات البيرازول المشتقة من النواتج الطبيعية ومثيلتها المصنعة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Abbass Mohamed Abdelrahman Selim , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 147 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Although the majority of drugs used in clinical practice are exclusively prepared synthetically, plants have always played an important role as a source of medicines. Ammi visnaga (khella) is a widely distributed ancient egyption medicinal plant. The furochromone khellin, the major constituent of ammi visnaga seeds has been used to treat a variety of diseases including renal colic, kidney stones, coronary diseases, bronchial asthma, vitilligo and psoriasis. In addition, several semisynthetic derivatives of khellin have been semisynthesized and tested for their various medicinal properties. The present investigation described the semisynthesis of certain new pyrazolylchalcones 106a,band their corresponding pyrazolylpyrazoline derivatives 107a-d starting from khellin. Also another series of pyrazolylchalcones 108a-c and their corresponding pyrazolylpyrazoline derivatives 109a-c and 110a-f derived from hydroxyacetophenones have been synthesized. In addition synthesis of new pyrazole derivatives 113a-c, 115a-c and 117-119 derived from 5-aminopyrazoles were described. All the semisynthesized and synthesized derivatives have been tested for their anti-inflammatory activity and selectivity through in vitro enzyme inhibition assay and the most active compounds were tested in vivo for their anti-inflammatory activity and showed good activity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-inflammatory |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | COX enzyme |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrazole |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Enas Ibrahim Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Abdelfattah Ragab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Yassin Mohammed Nissan Soliman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2020.Ah.S | 01010110081960000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2020.Ah.S | 01020110081960000 | 22.09.2023 | CD - Rom | 81960.CD |