MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03019cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
201109s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.Ph.D.2020.Ma.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Magdy Sayed Hassan |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Modified formulation of some radiolabed anticancer agents for nuclear medicine application / |
| Statement of responsibility, etc. |
Manal Magdy Sayed Hassan ; Supervised Mohamed Elnabarawi , Abeer Mohamed Amin , Abdulaziz Mohsen Almahallawi |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
صياغة مطورة لبعض مضادات السرطان المرقمة اشعاعيا لاستخدامها فى تطبيقات الطب النووى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Manal Magdy Sayed Hassan , |
| Date of publication, distribution, etc. |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
164 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
As the mortality due to cancer continues to rise, advances in nanotechnology have significantly become an effective approach for achieving efficient drug targeting to tumor tissues. Toxic chemotherapeutics given in their free form distribute broadly throughout the body, but by redirecting more of the drug dose towards tumor sites, reduced systemic side effects are expected, thus making anticancer treatment safer than conventional approaches . A recent interest in the use of self-assembled nanostructured materials for controlling the release of incorporated agents has been evolved. In the pharmaceutical area, viscous lipid-based systems, such as bicontinuous cubic liquid crystalline phases, offer considerable scope for application as drug delivery systems . Nanocubosomes are nano-structures composed mainly of amphiphilic polar lipid. When this amphiphilic substance dissolved in water with concentration above the critical micelle concentration, it forms micellar aggregations. At higher concentrations, the formed micelles are forced to form cubic structure . Alkylating agents, such as chlorambucil (4-[p-[bis [2-chloroethyl] amino] phenyl]-butanoic acid (CHB), are extensively used in the treatment of neoplastic diseases, such as chronic lymphocytic leukemia, lymphomas, advanced ovarian and breast cancer .However, chlorambucil use is limited by its toxic side effects, including myelotoxicity and neurotoxicity. These adverse profiles, limit the use of optimal doses of chemotherapeutic drug CHB. Consequently, protocols with sub-optimal doses are frequently used, minimizing toxicity and patient suffering but often resulting in inefficient treatment and unsatisfactory prognosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
¹²⁵I-Uridine |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nanocubosomal |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abdulaziz Mohsen Almahallawi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abeer Mohamed Amin , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Elnabarawi , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
