Anti-cancer effect of Egyptian propolis extract with or without chitosan nanospheres on tongue carcinoma cell line / (Record no. 78723)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03264cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032628.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201114s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.12.M.Sc.2020.Fa.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Fatma Abdelnasser Abdelrehim |
| 245 10 - TITLE STATEMENT | |
| Title | Anti-cancer effect of Egyptian propolis extract with or without chitosan nanospheres on tongue carcinoma cell line / |
| Statement of responsibility, etc. | Fatma Abdelnasser Abdelrehim ; Supervised Samah Sayed Mehanni , Zeinab Amin Ibrahim Salim , Hanan Hassan Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المضاد للسرطان لمستخلص دنج المصرى مع أو بدون كريات النانوكيتوزان على خط الخلايا السرطانية باللسان : |
| Remainder of title | دراسة فى المختبر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Fatma Abdelnasser Abdelrehim , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 123 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim of the study: Monitoring the anticancer effect of the Egyptian propolis methanolic extract with and without the chitosan nanospheres through ultrastructural histological study, COMET assay, the MTT assay and the miRNA expression. Materials and Methods: Tongue carcinoma cells were allowed to grow without any interventions and categorized as group I (gp I). Methanolic propolis extract was prepared from crude Egyptian propolis and applied on human tongue cancer cell line and categorized as group II (gp II) and then propolis nanopowders were loaded upon prepared chitosan nanospheres and applied again on a control human tongue cancer cell line and categorized as group III (gp III). The propolis and chitosan particle nanosize was confirmed by transmission electron microscopy. Phytochemical analysis for the propolis methanolic extract was made.The anticancer efficacy of the alcoholic extract alone and the combinational nanospheres of propolis and chitosan were investigated by cell proliferation assay (MTT assay), COMET assay, miRNA quantification by real-time PCR and the ultra structural changes were detected by transmission electron microscopy (TEM). Results: The results showed a significant cytotoxic effect on the cancer cells and detectable ultrastructural apoptotic changes in gp II and gp III. The cell viability assay (MTT) showed a significant drop in the cell viability from gp I to gp II and gp III at each time interval 24 hr and 48 hr COMET assay measuring the % of apoptosis proved the significant increase from gp I to gp II and gp III at both time intervals 24 hr and 48 hr. Moreover, miRNA 21 and miRNA 195 both were dropped significantly in gp II and gp III compared to gp I both at 24 and 48hrs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chitosan nanospheres |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tongue carcinoma cell line |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hassan Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samah Sayed Mehanni , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Amin Ibrahim Salim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.12.M.Sc.2020.Fa.A | 01010110082005000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.12.M.Sc.2020.Fa.A | 01020110082005000 | 22.09.2023 | CD - Rom | 82005.CD |