The ameliorating effect of melatonin hormone on the reproductive disorders and organ damage induced by hyperthyroidism in male rats / (Record no. 78740)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03427cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032628.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201114s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.16.M.Sc.2020.Ha.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hager Magdy Ramadan |
| 245 14 - TITLE STATEMENT | |
| Title | The ameliorating effect of melatonin hormone on the reproductive disorders and organ damage induced by hyperthyroidism in male rats / |
| Statement of responsibility, etc. | Hager Magdy Ramadan ; Supervised Hodallah Hatem Ahmed , Nadia Ahmed Taha |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المحسن لهرمون الميلاتونين على الاضطراب التناسلى وتلف الأعضاء الناشئ عن زيادة هرمونات الغدة الدرقية المستحث فى ذكور الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hager Magdy Ramadan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 242 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Animal Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study was carried out to investigate the effects of melatonin on the reproductive disorder and organ damage induced by hyperthyroidism. A total 75 male rats were divided into five groups 15 rats each: control group (distilled water containing 4M ammonium hydroxide in methanol and 1% absolute ethanol), L-thyroxine group (0.2 mg/kg), L-thyroxine plus melatonin (1, 5 and 10 mg/ kg), L-thyroxine and {u200F} melatonin were injected intraperitoneally daily for 21 days. Fasting blood samples were collected from each rat early in the morning at 11th day and at the end of the experiment, serum was separated, fasting blood glucose level was measured immediately after serum collection and the serum stored either at -20 {u02DA}C to be used for determination of liver function tests (AST, ALT and ALP), kidney function tests (creatinine level and urea concentration), lipogram (total cholesterol, triglycerides, HDL and LDL) and hormones (T4, T3, TSH, FSH, LH and testosterone) or at -80 {u02DA}C for determination of total antioxidants capacity. Five rats were scarified from each group in the 11th and at the end of the experiment and the following organs were collected to be used as follow Liver, kidney and heart were used for estimation of oxidant and antioxidant parameters (MDA, SOD and GSH), Liver and kidney were used for DNA damage and Liver, kidney, heart and testis were used for histopathological examination at the end of experiment. The results revealed that hyperthyroidism increased the levels of glucose, urea, liver enzymes activities, T3, T4, testosterone, percentage of DNA fragmentation and MDA concentration with histopathological alteration. At the same time hyperthyroidism decreased the performance traits, creatinine, lipogram, TSH, LH, FSH, total antioxidants capacity, SOD and GSH activity. Melatonin hormone could counteract the harmful effects of hyperthyroidism on the aforementioned parameters but couldn{u2019}t ameliorate the reproductive disorders |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Harmful effect |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | L-thyroxine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Melatonin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hodallah Hatem Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Ahmed Taha , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.16.M.Sc.2020.Ha.A | 01010110082014000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.16.M.Sc.2020.Ha.A | 01020110082014000 | 22.09.2023 | CD - Rom | 82014.CD |