MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03209cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201116s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.28.M.Sc.2020.Ra.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ramy Loka Nageh |
| 245 14 - TITLE STATEMENT |
|---|
| Title |
The prevalence of disease- related complications in Egyptian children and young adults with sickle cell disease receiving hydroxycarbamide / |
| Statement of responsibility, etc. |
Ramy Loka Nageh ; Supervised Amina Abdelsalam Mahmoud , Mai Mohamed Mohamed Abdelsalam , Mona Ahmed Kamel |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تأثير استخدام دواء الهيدروكسى كارباميد على مضاعفات مرض الأنيميا المنجليه فى الاطفال وصغار الشباب المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Ramy Loka Nageh , |
| Date of publication, distribution, etc. |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
145 P. : |
| Other physical details |
charts , facimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Although hydroxyurea has an established role in improving laboratory parameters and reducing acute clinical complications, its role in preventing organ damage in SCD is less well defined. Objectives: To assess the prevalence of disease- related complications in Egyptian patients with SCD receiving HU. Materials and Methods: This is a retrospective analytic study carried out on 60 SCD patients who were receiving HU therapy for at least 1 year. Details of HU therapy, clinical and laboratry data before and after HU were recorded. Results: All patients received HU at a starting dose 15 mg/kg/day with a maximum tolerated dose reached 35 mg/kg/day in 2 patients. Mean HU dose was 19 ± 4.9 mg/ kg/day and mean duration of HU treatment was 6.2 years.There was significant reduction in the frequency of vasoocclusive crises per year, frequency of blood transfusion and rate of hospitalization (p{u02C2}0.05). No significant difference was detected before and after using HU as regards the frequency infections, sequestration, aplastic crises, leg ulcers and cardiac complications (p{u02C3}0.05). One patient developed leg ulcers and another one had pulmonary hypertension while on HU. None of the studied patients had evidence of avascular necrosis at starting HU, however, eight (13.3%) patients developed bone changes while on HU. Two (3.4%) patients developed stroke while on HU and they were shifted to chronic transfusion regimen. There were a significant increases in total Hb, and significant decrease in TLC and reticulocytic count (p{u02C2}0.05). A statistically significant improvement of school scores among patients was seen after HU treatment (P=0.025). A marginally significant improvement of quality of life scores was detected among patients after using HU (P=0.05) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Disease related complications |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Egyptian children |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hydroxycarbamide |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amina Abdelsalam Mahmoud , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Mohamed Mohamed Abdelsalam , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mona Ahmed Kamel , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
