Grape seed and physalis extracts as anti- inflammatory agents in cetuximab induced tongue mucositis in rats : (Record no. 78856)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03709cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032632.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201119s2020 ua dho f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.14.Ph.D.2020.He.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Ahmed Saleh Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Grape seed and physalis extracts as anti- inflammatory agents in cetuximab induced tongue mucositis in rats : |
| Remainder of title | A comparative animal study / |
| Statement of responsibility, etc. | Heba Ahmed Saleh Ali ; Supervised Mona Ezzat Wali , Manar Abdulwaniss Mohammed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | مستخلصات بذور العنب و الحرنكش كعوامل مضادة للالتهاب فى التهاب الغشاء المخاطى لللسان الناجم عن سيتوكسيماب فى الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Ahmed Saleh Ali , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts , facsmilies , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis ( Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Oral mucositis (OM) is one of the common complications associated with cancer treatment. Several studies have suggested the use of neutraceuticals in conjunction with anti- cancerous agents aiming to reduce such inflammation which in turn, improves the quality of patient's life. In the present study, grape seed extract (GSE) and physalis extract (PE), known as potent anti-oxidant and anti-inflammatory neutraceuticals, were given to rats that were injected with the anti-cancerous drug Cetuximab (Cmab) to investigate their effect on tongue mucositis induced by the drug. The current study was designed to be conducted on 60 rats which were equally divided into 6 groups. Four groups were obtained from paraffin blocks of a previously performed study. One group (I) was left without any intervention to rule out the association of any result with the environmental factors. The remaining five groups were injected with anti-cancer drug Cmab. Among these groups taking Cmab drug, there is one group taking Cmab drug only while two groups of them were given GSE but one of them at time of administration of Cmab drug (IIIa) and the other group were given GSE one week ahead of Cmab drug (IIIb). The remaining groups were given PE, one of them simultaneously with Cmab drug (IVa) and the other was given PE one week ahead of Cmab administration (IVb). A ready manufactured GSE was available while PE is prepared in national research center lab from fresh fruits collected from Egyptian farms. Then, euthanasia of all groups of rats was done on the 16th day from the start of Cmab drug infusion. Biopsies were dissected from rats and prepared for histological examination. Changes in number of filiform papillae and also the number of mast cells detected by anti- mast cell tryptase antibody were assessed. Furthermore, apoptosis was also evaluated via measuring the area percent of immunohistochemical expression of bax and bcl2 in sections of tongue mucosa of rats in all groups and then calculating bax/bcl2 ratio. Bcl-2 is an antiapoptotic protein while bax is a proapoptotic protein and high ratio of bax/ bcl-2 is considered an indicator for enhancement of apoptosis as reported before in many studies done to test the effect of anti-cancerous treatment |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cetuximab |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Grape seed |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Physalis extracts |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manar Abdulwaniss , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Ezzat Wali , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.14.Ph.D.2020.He.G | 01010110082101000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.14.Ph.D.2020.He.G | 01020110082101000 | 22.09.2023 | CD - Rom | 82101.CD |