Effect of lactobacillus/metronidazole alone or in combination with metformin in rats with non-alcoholic fatty liver : (Record no. 78916)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03542cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032635.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201123s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Ma.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Maha Badr Mohamed Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of lactobacillus/metronidazole alone or in combination with metformin in rats with non-alcoholic fatty liver : |
| Remainder of title | Possible modulation of gut short chain fatty acids and autophagy / |
| Statement of responsibility, etc. | Maha Badr Mohamed Mohamed ; Supervised Samira Saleh Mostafa , Lamiaa Ahmed Ahmed Attia , Sanaa Sabet Botros |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فاعلية الكتوباسلس/ ميترونيدازول بمفردهما أو بصحبة ميتفورمين فى الجرذان المصابة بتدهن الكبد غير الكحولى : |
| Remainder of title | لتعديل المحتمل فى الأحماض الدهنية المعوية قصيرة السلسلة وآلية الإلتهام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Maha Badr Mohamed Mohamed , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Non-alcoholic fatty liver disease is considered one of the major troubling diseases worldwide since we are moving towards a gradual reduction of viral hepatitis and a progressive increase in obesity and type-2 diabetes mellitus. Moreover, gut microbiota is a crucial factor in pathogenesis of simple steatosis (SS) and non-alcoholic steatohepatitis (NASH).Therefore, targeting the gut{u2013}liver axis might be a novel therapeutic approach to treat SS and NASH.This study aimed to investigate the therapeutic effects of using a probiotic (Lactobacillus reuteri) and metronidazole (MTZ) (an antibiotic against Bacteroidetes) either alone or in combination with metformin (MTF) in experimentally-induced SS and NASH. SS and NASH were induced by feeding rats with high fat diet (HFD) for 6 or 12 weeks, respectively. MTF (150 mg/kg/day) or L. reuteri (2x109 colony forming unit/day) were given orally for either 6 or 8 weeks to treat either SS or NASH, respectively; meanwhile, MTZ (15 mg/kg/day, p.o.) was administered for 1 week. Treatment with L. reuteri and MTZ in combination with MTF showed additional benefit compared to MTF alone concerning liver function, oxidative stress, lipid profile, inflammatory and autophagy markers. Furthermore, the combined regimen succeeded to modulate acetate: propionate: butyrate ratios as well as Firmicutes and Bacteroidetes fecal content with improvement of insulin resistance. Yet, the administration of MTF alone failed to normalize Bacteriodetes and acetate contents which could be the reason of its moderate effect. In conclusion, gut microbiota modulation may be an attractive therapeutic avenue against NASH. In conclusion, more attention should be paid deciphering the crosstalk mechanisms linking gut microbiota to non-alcoholic fatty liver disease to identify new therapeutic targets for this disease |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Lactobacillus reuteri |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metronidazole |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Non-alcoholic fatty liver |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed Ahmed Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samira Saleh Mostafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Sabet Botros , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Ma.E | 01010110082126000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Ma.E | 01020110082126000 | 22.09.2023 | CD - Rom | 82126.CD |