The potential protective effect of certain natural products on carbon tetrachloride - induced hepatotoxicity / (Record no. 78958)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03033cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032636.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201124s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Re.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Mohamed Galal Yehia |
| 245 14 - TITLE STATEMENT | |
| Title | The potential protective effect of certain natural products on carbon tetrachloride - induced hepatotoxicity / |
| Statement of responsibility, etc. | Reem Mohamed Galal Yehia ; Supervised Sanaa A. Kenawy , Hala F. Zaki , Lamiaa Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إمكانية وقاية الكبد باستخدام بعض المنتجات الطبيعية من التسمم المحدث برباعى كلوريد الكربون فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Mohamed Galal Yehia , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 197 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatotoxic injury can have several forms including necrosis, steatosis, fibrosis, cirrhosis and carcinoma. The present study was undertaken to investigate the possible protective effects of quercetin (50 mg/kg), lecithin (100 mg/kg) and their combination versus silymarin (100 mg/kg) as a reference standard against carbon tetrachloride-induced hepatotoxicity. Methods: Male Wistar rats were divided into eight groups where CCl4 (0.5 ml/kg; p.o.; twice/week for 4 weeks) was administered to all groups except the first group that served as normal group. The second group received only CCl4 (0.5 ml/kg, p.o.). Group III, IV and V received orally silymarin (100 mg/kg), quercetin (50 mg/kg) and lecithin (100 mg/kg), respectively. Group VI received orally a combination of silymarin (100 mg/kg) and quercetin (50 mg/kg). Group VII received orally a combination of silymarin (100 mg/kg) and lecthin (100 mg/kg) while group VIII received orally a combination of quercetin (50 mg/kg) and lecithin (100 mg/kg). Results: CCl4 caused marked liver damage as manifested by significant increase in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and alpha-feto protein (AFP) serum levels together with decrease in total protein and albumin serum levels. It also resulted in a significant decrease in liver reduced glutathione (GSH) and total antioxidant capacity (TAC) hepatic contents parallel to a significant increase in malondialdehyde (MDA), inducible nitric oxide synthase (iNOS), nitric oxide (NO), tumor necrosis factor-alpha (TNF-Ü) and hydroxyproline (HP) hepatic contents |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carbon tetrachloride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxic injury |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala F. Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa A. Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Re.P | 01010110082171000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Re.P | 01020110082171000 | 22.09.2023 | CD - Rom | 82171.CD |