A pharmaceutical study on an antihistaminic drug for topical application / (Record no. 78998)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03130cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032637.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201129s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2020.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sandy Nashat Youssef Aziz |
| 245 12 - TITLE STATEMENT | |
| Title | A pharmaceutical study on an antihistaminic drug for topical application / |
| Statement of responsibility, etc. | Sandy Nashat Youssef Aziz ; Supervised Alia Abdellatif Badawi , Demiana I. Nesseem , Nevine S. Abdelmalak |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلية على عقار مضاد الهيستامين للإستعمال الخارجى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sandy Nashat Youssef Aziz , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diphenhydramine hydrochloride is one of the famous first generation H1 antihistaminic drugs that are used in the treatment of skin allergy. It reduces the actions of histamine in the body by competitive blockade of histamine H1 receptor sites on tissues. When orally taken, diphenhydramine hydrochloride is easily able to penetrate the blood brain barrier and occupy H1 receptor sites in the brain, resulting in fatigue, drowsiness, and performance impairment. Meanwhile conventional topical gels of diphenhydramine hydrochloride showed less patient compliance due to increased frequency of application on the skin to reach better therapeutic effect. Diphenhydramine hydrochloride loaded nanoparticles were prepared using different natural polymers and simple techniques for preparation. These nanoparticles could provide targeted therapy with enhanced skin delivery and prolonged anti-allergic effect .Consequently; this will lead to improvement in patient complianceThe aim of this work: 1. Preparation of diphenhydramine hydrochloride loaded nanoparticles containing adequate amount of drug to achieve better therapeutic effects than conventional topical gel preparations. 2. Prolongation of the therapeutic effect of diphenhydramine hydrochloride loaded nanoparticles which lead to decreased frequency of application of the drug in comparison to conventional topical gel preparations. 3. Improve patient compliance. Thus the work in this thesis was divided into three chapters: Chapter 1: Preparation and evaluation of diphenhydramine hydrochloride loaded chitosan nanoparticles. Chapter2: Preparation and evaluation of diphenhydramine hydrochloride loaded alginate/chitosan nanoparticles. Chapter3: In-vivo performance of the selected diphenhydramine hydrochloride loaded nanoparticles |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antihistaminic drug |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diphenhydramine hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Skin allergy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alia Abdellatif Badawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Demiana I.Nesseem , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine S. Abdelmalak , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2020.Sa.P | 01010110082177000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2020.Sa.P | 01020110082177000 | 22.09.2023 | CD - Rom | 82177.CD |