Effect of post-surgical tumor microenvironment fluid on the breast cancer stem cell properties / (Record no. 79010)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03162cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032637.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201129s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Al.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alshaimaa Tarek Ismail Abdelfatah |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of post-surgical tumor microenvironment fluid on the breast cancer stem cell properties / |
| Statement of responsibility, etc. | Alshaimaa Tarek Ismail Abdelfatah ; Supervised Mona Mostafa Mohamed , Sherif Abdelaziz Ibrahim , Mohamed Elsayed Elshinawi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير سائل البيئة الدقيقة من مكان استئصال الورم بعد الجراحة على خصائص الخلايا الجذعية لسرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Alshaimaa Tarek Ismail Abdelfatah , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Modified radical mastectomy (MRM) one of conventional treatment of breast cancer was suggested by many evidences that sometimes there is a relation between surgery and tumor recurrence. Most of breast local recurrences occur at the same quadrant of the primary cancer, suggesting that the tumor recurrence may promote from residual cancer cells and/ or quiescent stem cells lasting after surgery in tissues left behind after MRM. CSCs, a subpopulation of cancer cells, are characterized by self-renewal, unlimited and high proliferative potential and apoptosis resistance and the expression of specific cell surface markers. Breast cancer chemo and/or radio resistance, local recurrences and distant metastasis may originate from residual tumor cells and cancer stem cells (CSCs) left behind in the cavity after breast cancer surgery. We hypothesized that the residual malignant cells or quiescent CSCs may be activated by post-surgical tumor microenvironment fluid resulting at the surgical site through factors that are released in response to inflammation. In the present study post-surgical tumor microenvironment fluid were collected within 24 hrs of breast surgery in sterile tubes and filtered. The proteomic composition of post-surgical tumor microenvironment fluid was characterized using RayBio{u2122}human cytokine antibody Post-surgical tumor microenvironment fluid was used to stimulate MDA-MB-231 to test its effect on cell viability by MTT assay. Additionally, expression of CD44/CD24 stem-like surface markers was evaluated for MDA-MB-231 and SUM-149 breast cancer cell lines using Flow Cytometry. Moreover, EMT marker E-cadherin was assessed using immunofluorescence |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Post-surgical tumor microenvironment fluid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Surgery |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Elsayed Elshinawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mostafa Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Abdelaziz Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Al.E | 01010110082197000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Al.E | 01020110082197000 | 22.09.2023 | CD - Rom | 82197.CD |