A study to evaluate the protective effect of green tea catechins against isoniazid-induced hematological and biochemical adverse reactions in rats / (Record no. 79054)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03343cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032639.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201202s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Ei.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Eiman Ismael Mohamed Rayan |
| 245 12 - TITLE STATEMENT | |
| Title | A study to evaluate the protective effect of green tea catechins against isoniazid-induced hematological and biochemical adverse reactions in rats / |
| Statement of responsibility, etc. | Eiman Ismael Mohamed Rayan ; Supervised Osama Abdelghaffar Youssef |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة لتقييم التأثير الوقائى لكاتيكينات الشاى الأخضر ضد التفاعلات العكسية الهيماتولوجية والبيوكيميائية الناجمة عن الأيزونيازيد فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Eiman Ismael Mohamed Rayan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 225 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of this study was to evaluate the protective role of the green tea catechins (GTC) against the isoniazid (INH)-induced oxidative stress and associated hematological and biochemical alterations in rats. One hundred male albino rats were divided into four groups: (i) control, (ii) INH-treated, (iii) (INH+GTC)-treated and (iv) GTC-treated groups. In the 2nd and 3rd groups, INH was orally administered at a dose level of 27 mg/kg b.wt., which was equivalent to the therapeutic dose of humans, daily for five weeks. In the 3rd group, GTC were orally administered at a dose level of 50 mg/kg b. wt. one hour prior to INH administration, daily for five weeks. In the 4th group, GTC were orally administered to the animals daily for five weeks at dose level of 50 mg/kg b. wt. From each group, five animals were weekly taken out for sampling of blood and liver.The administration of INH resulted in a normocytic normochromic anemia and leukopenia. Leukopenia was a direct consequence of the reduction in absolute counts of neutrophils, eosinophils, lymphocytes and monocytes. In INH-treated rats, significant increments were observed in serum total cholesterol, LDL-cholesterol, atherosclerotic indices and triglyceride levels whereas HDL-cholesterol level was decreased. Serum total protein and albumin levels were reduced whereas serum globulin level was slightly increased. Serum urea and creatinine levels were not altered in INH-treated rats. Liver function markers (ASAT, ALAT, ALP, total and direct bilirubin) were elevated by the INH administration being indicative to the hepatic damage. Lipid peroxidation was evidenced through the increased level of liver malondialdehyde (MDA) concentrations. The endogenous antioxidant system showed noticeable decrements in liver glutathione (GSH) content and the activities of liver superoxide dismutase (SOD) and catalase (CAT) and erythrocyte glucose-6-phosphate dehydrogenase (G6PD |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-TB drugs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Isoniazid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Osama Abdelghaffar Youssef , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ei.S | 01010110082215000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ei.S | 01020110082215000 | 22.09.2023 | CD - Rom | 82215.CD |