Design, synthesis and biological evaluation of some new barbituric acid derivatives with anticipated anticancer activity / (Record no. 79098)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02070cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032640.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201205s2020 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2020.No.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noura Sayed Hanafy Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and biological evaluation of some new barbituric acid derivatives with anticipated anticancer activity / |
| Statement of responsibility, etc. | Noura Sayed Hanafy Mahmoud ; Supervised Samir Mohamed Elmoghazy , Riham Francois George , Essam Eldin Abdelfattah Osman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم: تشييد وتقييم بيولوجى لبعض مشتقات حمض الباربيتيوريك الجديدة ذات نشاط متوقع كمضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noura Sayed Hanafy Mahmoud , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This work deals with the design and synthesis of some novel pyrimidinone derivatives; Va-e, VIa-e, VIIa-e, Xa-d, XIa-d and XIIa-d as PARP-1 inhibitors. Molecular modeling techniques were used to support the design.The twenty seven newly synthesized compounds were evaluated for their ability to inhibit PARP-1.The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines.The most active compounds against PARP1 in vitro were evaluated in the BRCA1 mutated breast cancer cell line MDA-MB-436 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Molecular docking |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PARP-1 inhibitors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrimidinones |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Essam Eldin Abdelfattah Osman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riham Francois George , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Mohamed Elmoghazy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2020.No.D | 01010110082257000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2020.No.D | 01020110082257000 | 22.09.2023 | CD - Rom | 82257.CD |