Amelioration of copper oxide nanoparticles-induced oxidative stress by dehydroepiandrosterone either alone or in combination with Quercetin on rat liver : (Record no. 79099)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03233cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032640.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201205s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.Ph.D.2020.Sh.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shams Gamal Eldin Amin Shams |
| 245 10 - TITLE STATEMENT | |
| Title | Amelioration of copper oxide nanoparticles-induced oxidative stress by dehydroepiandrosterone either alone or in combination with Quercetin on rat liver : |
| Remainder of title | In vitro and in vivo study / |
| Statement of responsibility, etc. | Shams Gamal Eldin Amin Shams ; Supervised Samy Abdelfatah Abdelazim , Hanan Farouk Aly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحسين التوتر التأكسدى الناجم عن جسيمات اوكسيد النحاس النانويه بواسطة الديهيدروابيندروستيرون على حدة او مقترنا مع الكيرستين فى كبد الجرذان : |
| Remainder of title | دراسة معملية وفي داخل الجسم الحى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shams Gamal Eldin Amin Shams , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 136 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study aimed to clarify the effect of Copper oxide nanoparticles (CuO NPs) on hepatocellular carcinoma HepG2 cells in vitro and on normal rat liver in vivo. In addition, evaluation of the therapeutic efficacy of individual or combined doses of dehydro-epiandrosterone (DHEA) and quercetin in ameliorating some biochemical indices in liver of CuO NPs intoxicated-rats. CuO NPs (50nm) was administered at a dose of 100 mg/Kg for two weeks to rats followed by the fore-mentioned antioxidants for 3 weeks. In the present study, we highlighted the therapeutic effect of DHEA and/or quercetin against CuO NPs toxicity through monitoring the alteration of liver enzyme markers, antioxidant defense mechanism, necrosis, apoptosis, hepatic histopathological alterations, and DNA damage.The rats given CuO NPs only showed marked significant elevation in liver enzymes, alteration in oxidant-antioxidant balance and an elevation in the hepatic inflammatory marker; tumor necrosis factor-Ü (TNF-Ü). Additionally, over expression of both caspase-3 and Bcl2 associated X protein were detected. Whereas, B-cell lymphoma-2 was down regulated and DNA fragmentation was elevated. Moreover, histopathological examination of hepatic tissue reinforced the previous biochemical results.Treatment with either DHEA, quercetin alone or in combination ameliorated the deviated parameters against CuO NPs toxicity in rat with variable degrees.In conclusion, our findings suggest that the fore-mentioned treatments exert therapeutic effect in CuO NPs toxicity by diminishing oxidative stress, mRNA gene expression and hepatic tissues DNA damage |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Copper oxide nanoparticles |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dehydroepiandroestrone |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Farouk Aly , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samy Abdelfatah Abdelazim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.Ph.D.2020.Sh.A | 01010110082258000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.Ph.D.2020.Sh.A | 01020110082258000 | 22.09.2023 | CD - Rom | 82258.CD |