Study of the role of empagliflozin in experimentally induced cardiac dysfunction in rats / (Record no. 79149)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03311cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032641.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201207s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2020.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Ahmed Abbas Khattab |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the role of empagliflozin in experimentally induced cardiac dysfunction in rats / |
| Statement of responsibility, etc. | Mahmoud Ahmed Abbas Khattab ; Supervised Fatma Ahmed Elbatrawy , Omayma Anwar Khorshid , Ghada Farouk Saleh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دور الٳيمباجلفلوزين على إعتلال وظائف القلب المحدثة تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mahmoud Ahmed Abbas Khattab , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 140 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: This experimental study was done to investigate the role of empagliflozin in cardiac dysfunction induced in rats by three different models. Materials and methods: 64 male Sprague Dawley Albino rats were used in this study for 13 weeks and divided into 8 groups (n=8). 1A, 1B-Control groups where rats in 1A received 1ml saline daily by oral gavage for 8 weeks then in 1B treated with empagliflozin started from 8th week at dose of (10 mg/kg) daily by oral gavage for 5 weeks. Groups 2A&B, 3A&B were subjected to High Salt Diet (HSD), High Fat Diet group (HFD) for 8,7 weeks respectively then treated with empagliflozin in groups 2B, 3B daily for further 5 weeks. Group 4A&B were injected with Doxorubicin (DOX) intraperitoneally at weekly doses of 5 mg/kg for 5 weeks then treated with empagliflozin in group 4B for further 5 weeks. Body weight (BW), Systolic blood pressure (SBP), Electrocardiography (ECG), Echocardiography were recorded at the start, 8th week and at the end of the experiment. Heart /Body weight (HW/BW) ratio an index of cardiac hypertrophy was measured. At the end of the study, blood samples were taken for estimation of serum glucose, cholesterol, triglycerides and (BNP) levels. The isolated heart tissue was homogenized for estimation of (TNFÜ) and (MDA). Results: Empagliflozin showed dramatic effect in improving the cardiac dysfunction in the different models. It lowers BW in control & HFD treated groups, increased BW in DOX treated group, decreased blood pressure in control, HSD & HFD treated groups, decrease in HW/BW ratio in all groups. Moreover, The ECG ischemic changes were improved in HFD treated group and QT prolongation was prevented in DOX treated group with no changes observed in HSD treated group. Also, Empagliflozin resulted in significant improvement of systolic and diastolic function and prevention of the dilated cardiomyopathic effect noted in DOX treated group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Empagliflozin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | High Fat Diet |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | High salt Diet |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Ahmed Elbatrawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Farouk Saleh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omayma Anwar Khorshid , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2020.Ma.S | 01010110082287000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2020.Ma.S | 01020110082287000 | 22.09.2023 | CD - Rom | 82287.CD |