Synthesis of some fused heterocyclic compounds incorporating isoquinoline moiety with expected biological activity / (Record no. 79265)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03060cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032645.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201219s2020 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.M.Sc.2020.Ya.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yara Nour Eldin Mohamed Laboud |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some fused heterocyclic compounds incorporating isoquinoline moiety with expected biological activity / |
| Statement of responsibility, etc. | Yara Nour Eldin Mohamed Laboud ; Supervised Hyam A. Abdelhadi , Mohamed A. Mohamed Teleb , Fatma M. Saleh |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير بعض المركبات الملتحمة غير متجانسة الحلقة متضمنة جزئية الأيزوكينولين و المتوقع لها نشاط بيولوجى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yara Nour Eldin Mohamed Laboud , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present dissertation describes the utility of isoquinoline derivatives in the synthesis of new heterocyclic compounds by treatment of 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1- yl)acetonitrile 1 with arylisothiocycnates 2a-c in refluxing toluene to afford thioanilide derivatives 3, which converted to the corresponding thiadiazole derivatives 5A-P upon refluxing with Ü-ketohydrazonoyl halides 4A-P in chloroform in the presence of triethylamine. Refluxing of thiadiazoles 5A-C with N,N-dimethylformamide dimethylacetal afforded enaminones 11A-C. Also, study the Michael addition reaction of enaminones 14a-d with compound 1 in refluxing ethanol in the presence of piperidine to yield 4H-pyrido[2,1-a]isoquinoline-1-carbonitrile derivatives 16a-d. Also, reaction of and ethyl 3-aryl-2-cyanoacrylate 19a-g with compound 1 under the same previous conditions, using acetonitrile instead of ethanol, gave 4H-pyrido[2,1- a]isoquinoline-1,3-dicarbonitrile derivatives 23a-g. Stirring of aldehydes 24a-i with 1 in absolute ethanol in the presence of concentrated hydrochloric acid gave the corresponding arylidene derivatives 25, which converted to 5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carbonitrile derivatives 28a-g by refluxing with Ü-ketohydrazonoyl halides 4A,G,K in chloroform in the presence of triethylamine. The structures of the new heterocyclic compounds prepared were established on the basis of elemental analysis and spectral analyses (IR, ¹H NMR, ¹³C NMR, MS). Also, some of the new compounds were tested for their antibacterial and antifungal activities |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thiadiazole |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ü- ketohydrazonoyl halide |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma M. Saleh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hyam A. Abdelhadi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed A. Mohamed Teleb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.M.Sc.2020.Ya.S | 01010110082338000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.M.Sc.2020.Ya.S | 01020110082338000 | 22.09.2023 | CD - Rom | 82338.CD |