Relation of serum level of tumor necrosis factor {u2013} alpha to cognitive functions in patients with parkinson{u2019}s disease / (Record no. 79291)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03286cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032646.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201223s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.21.M.Sc.2020.Sa.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Refaat Shazly |
| 245 10 - TITLE STATEMENT | |
| Title | Relation of serum level of tumor necrosis factor {u2013} alpha to cognitive functions in patients with parkinson{u2019}s disease / |
| Statement of responsibility, etc. | Sara Refaat Shazly ; Supervised Manal Mahmoud Elkattan , Rania Shehata Mohamed , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | علاقة مستوى معامل نخر الورم {u٢٠١٣} ألفا فى الدم بالوظائف المعرفيه فى مرضى داء باركنسون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sara Refaat Shazly , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Parkinson{u2019}s disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease. However, at present, the pathophysiology and clinical management of these symptoms are poorly understood. Objectives: The present study aimed to investigate the association between serum TNF-Ü level and cognition in PD patients, and to examine their relation to clinical presentation and disease severity. Methods: Thirty diagnosed PD patients and thirty healthy controls were included in this study. Patients were subjected to complete clinical assessment and Unified Parkinson Disease Rating Scale (UPDRS) was done to evaluate severity of PD. Cognitive assessment using Addenbrooke{u2019}s Cognitive Examination (ACE-III) and trail making B test and measurement of serum levels of TNF-Ü were done for both patients and controls. Results: The patients showed significant worse performance than controls in the cognitive assessment scales except for language subset of ACE score.Mean serum TNF-Ü level was significantly higher in PD patients compared to controls.TNF-Ü serum level was significantly negatively correlated with ACE language but not with age, age at onset, duration of the disease, UPDRS and H&Y scores. Sensitivity and specificity of TNF-Ü to detect cognitive impairment in PD using ACE III and trail making B were (73.1, 75%), (57.1, 56.2 %) respectively .Whereas, sensitivity and specificity of TNF-Ü to detect severity of PD using H&Y staging in PD were 50%. Conclusion: cognitive impairment is commonly encountered in PD patients. Elevated serum levels of TNF-Ü in PD patients implicate this proinflammatory cytokine in the pathophysiology of the disease |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ACE-III |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cognitive functions |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Parkinson{u2019}s disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Manal Mahmoud Elkattan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Shehata Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.21.M.Sc.2020.Sa.R | 01010110082372000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.21.M.Sc.2020.Sa.R | 01020110082372000 | 22.09.2023 | CD - Rom | 82372.CD |