A pharmaceutical study on an osmotic controlled delivery of a poor water soluble drug / (Record no. 79409)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03402cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032650.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210102s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2020.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sami Mohamed Awadalla Mohamed |
| 245 12 - TITLE STATEMENT | |
| Title | A pharmaceutical study on an osmotic controlled delivery of a poor water soluble drug / |
| Statement of responsibility, etc. | Sami Mohamed Awadalla Mohamed ; Supervised Magdy Ibrahim Mohamed , Abdulaziz Mohsen Almahallawi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلانية على توصيل أوزموزى محكم لعقار ضعيف الذوبان فى الماء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sami Mohamed Awadalla Mohamed , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diacerine (DCN) is an anti-osteoarthritic drug with low bioavailability.In an attempt to overcome this drawback,thirty nine ternary solid dispersion formulae were designed by ordinary fusion method using carrier polymers such as either Pluronic® F127(PF127), Solutol®HS15 or Polyethylene Glycol 35K (PEG 35K)with different weight ratio and constant weight of drug. They were optimizedby face-centered central composite statistical design and evaluated for the saturated solubility, initial dissolution rate in 5minutes (IDR5min) and cumulative drug release at 40 and 60 minutes(Q40min, Q60min respectively) as responses. Then rotatable central composite design was conducted to optimize the release profile of osmotic pump tablets that contained optimum DCN solid dispersion. Furthermore the in-vivo performance of the optimized osmotic formula was assessed on healthy rabbits.The optimized solid dispersion formula was DCN:PF127:Solutol®HS 15 with ratio 1:1:1; that showed the significant improvement in the initial dissolution rate with approximately4.86±0.95æg % / min of the drug released in the first 5 min, 67.635±3.1 %, 80.28±4.5 % at Q40min and Q60minrespectively. Furthermore the saturated solubility of optimized DCN solid dispersion;was 62.91±4.8 æg/ml; more than pure DCN which corresponds to a 5.9 fold difference.On optimization of asymmetric osmotic pump tablets, it was found that the drug release was inversely proportional to coat concentration of the membrane and concentration of gelling polymer, while it was directly proportional to the amount of osmogen. The optimized formula had the following parameters; coat concentration (Opadry® CA) was 3%w/v, gelling polymer (HPMC E15) was 1%w/w and osmogen concentration (NaCl) was 35.8%w/w. The results also displayed the reliability of this system to control the release of drug at zero order kinetic for up to 24 hours. The in vivo studies conducted on rabbits revealed a significant enhancing in bioavailability of the optimized osmotic pump (28.84±3.32 ng.hr/ml) compared to pure DCN (10.39±1.45 ng.hr/ml) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Bioavailability |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diacerine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ternary solid dispersion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdulaziz Mohsen Almahallawi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ibrahim Mohamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2020.Sa.P | 01010110082437000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2020.Sa.P | 01020110082437000 | 22.09.2023 | CD - Rom | 82437.CD |