Study of the possible hepatoprotective effects of some phytochemical agents against valproic acid-induced liver toxicity in rats / (Record no. 79472)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03066cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032652.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210104s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.We.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wessam Hamdy Abdelaziz Elesawy |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the possible hepatoprotective effects of some phytochemical agents against valproic acid-induced liver toxicity in rats / |
| Statement of responsibility, etc. | Wessam Hamdy Abdelaziz Elesawy ; Supervised Mohammed Elyamany , Hala M. Fawzy , Noha Fawzy Hamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثير الوقائى المحتمل لبعض المواد الطبيعية فى التسمم الكبدى المحدث باستخدام دواء حمض فالبرويك فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Wessam Hamdy Abdelaziz Elesawy, |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Valproic acid is a commonly used drug for many psychiatric disorders, particularly for epilepsy. However, it has been reported that its use is associated with possible side effects including hepatotoxicity. The present study investigated the hepatoprotective effect of some phytochemical agents against valproic acid-induced hepatotoxicity in rats. Caffeic acid (50 mg/kg/day; p.o), cinnamic acid (50 mg/kg/day; p.o) and ellagic acid (60 mg/kg/day; p.o) were administered for 21 days, and VPA (250 mg/kg/day; i.p.) was given starting from the 8th day, for 14 consecutive days to induce hepatocellular damage in adult Sprague-Dawley rats. Valproic acid showed a marked increase in serum enzyme activities, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (Þ-GT). In addition, it significantly increased malondialdehyde (MDA) and nitric oxide (NO) along with a marked decline in reduced glutathione content (GSH). At the same time, valproic acid administration resulted in marked elevation in hydroxyproline, tumor necrosis factor-Ü production (TNF-Ü), alpha smooth muscle actin (Ü-SMA) and nuclear factor-kappa B (NF-mB) expression. These results were confirmed by histopathological and immunohistochemical examination. Treatment with caffeic acid, cinnamic acid or ellagic acid markedly attenuated valproic acid-induced injury by suppression of oxidative/nitrosative stress and inflammation, amendment of antioxidant defenses, as well as improvement of hepatocellular histological features |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cinnamic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Valproic acid Caffeic acid |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala M. Fawzy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Elyamany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Fawzy Hamed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.We.S | 01010110082513000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.We.S | 01020110082513000 | 22.09.2023 | CD - Rom | 82513.CD |