The role of endocrine versus paracrine fibroblast growth factor and nuclear factor of activated Tcell (NFAT) signaling in cardiac remodeling and development of uremic cardiomyopathy / (Record no. 79657)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03581cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032658.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210123s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.M.Sc.2020.Ne.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nermeen Sherif Mahfouz Hafez |
| 245 14 - TITLE STATEMENT | |
| Title | The role of endocrine versus paracrine fibroblast growth factor and nuclear factor of activated Tcell (NFAT) signaling in cardiac remodeling and development of uremic cardiomyopathy / |
| Statement of responsibility, etc. | Nermeen Sherif Mahfouz Hafez ; Supervised Hania Ibrahim Ammar , Heba Samy Ibrahim , Asmaa Mohammed ShamsEldeen |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور عوامل نمو الخلايا الليفية (الهرمونية والغير هرمونية) فى اعادة تشكيل القلب وتطور اعتلال عضلة القلب الناتج عن مرضى الكلى المزمن - اعتلال القلب اليوريمى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nermeen Sherif Mahfouz Hafez , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background, left ventricular hypertrophy (LVH) is one of the major cardiovascular complication of Chronic kidney disease (CKD). Activation of fibroblast growth factor receptor (FGFR4 and 1) may contribute to the complex pathogenesis of LVH. The aim of this work was to evaluate the therapeutic and prophylactic role of the small molecule inhibitor of FGFR4 (BLU9931) and the small molecule inhibitor of FGFR1 (AZD4547) in alleviating uremic cardiomyopathy. Methods, CKD was induced in rats by 5/6 subtotal nephrectomy operation. fifty Adult male Wistar rats were randomly divided into five groups as follows: (1) Control group, (2) Sham {u2013}operated group, (3) 5/6 subtotal nephrectomy group, (4) 5/6 subtotal nephrectomy + FGFR4 inhibitor: BLU9931 {RF B1}, (5) 5/6 subtotal nephrectomy + FGFR1 inhibitor: AZD4547{] RF B2}. Arterial Blood pressure, electrocardiography ECG and echocardiography ECHO measurement and serum urea and creatinine were recorded in all groups. Results, administration of both the small molecule FGFR4 inhibitor BLU9931 and the small molecule FGFR1 inhibitor AZD4547 2 weeks after the operation resulted in amelioration of cardiac hypertrophy in both RF B1 and RF B2 group at the fifth week. By analysis of echocardiography data, a significant decline in IVSd and LVPWd thicknesses were observed in both RF B1 and RF B2 groups back to the control value. On the other hand, there was no changes in EF% and FS% throughout the study in RF B1 and RF B2. Also, we report significant decrease in the serum urea and serum creatinine in both treated groups. Conclusion, the results of the present study suggested that administration of the small molecule inhibitor of FGFR4: BLU9931 and the small molecule AZD4547 inhibitor of FGFR1 Combined with proper control of renal hypertension can be an early effective prophylactic treatment for preventing adverse uremic cardiovascular complications |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cardiovascular disease (CVD) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chronic kidney disease (CKD) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | left ventricular hypertrophy (LVH) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Mohammed Shams Eldeen , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hania Ibrahim Ammar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Samy Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.M.Sc.2020.Ne.R | 01010110082564000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.M.Sc.2020.Ne.R | 01020110082564000 | 22.09.2023 | CD - Rom | 82564.CD |