Synthesis of some thiophene derivatives of expected anti-inflammatory activity / (Record no. 79727)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03049cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210125s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.Ph.D.2020.Ah.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelmohsen Abdellatif Ibraheem |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some thiophene derivatives of expected anti-inflammatory activity / |
| Statement of responsibility, etc. | Ahmed Abdelmohsen Abdellatif Ibraheem ; Supervised Salwa Elsayed Mohamed Elmeligie , Nadia Abdalla Khalil , Hala Bakr Elnassan |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد بعض مشتقات الثيوفين ذات تأثير محتمل كمضادات للالتهاب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Abdelmohsen Abdellatif Ibraheem , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 158 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis comprises five chapters. The first chapter is an introduction, which highlights the pharmacological importance of some thieno[3,2-d]pyrimidine derivatives, and briefly reviews the different synthetic strategies used for their synthesis. Further, it touches on the role of p38Ü mitogen activated protein kinase (MAPK) in inflammation, its tertiary structure, and its inhibition using small molecule inhibitors. The second chapter demonstrates the aim of this work along with proposed Schemes detailing the pathways used for the synthesis of the starting materials, intermediates, and the new target compounds. Scheme 1 illustrates the synthesis of the intermediate compounds IIIa-c and IVa-k. Nitration of p-toluidine and p-anisidine using urea nitrate afforded the corresponding 3-nitro derivatives Ib, c. The latter compounds, along with the commercially available 3-nitroaniline (Ia), were reacted with benzoyl chloride to afford the corresponding benzamides IIa-c, which were subsequently subjected to iron-catalyzed reduction reaction to give the benzamides IIIa-c. Reaction of the latter as well as some commercially available substituted anilines, with chloroacetyl chloride afforded 2-chloro-N-(substituted phenyl)acetamides IVa-k.Scheme 2 describes the synthesis of the tetrasubstituted thiophenes VIIa-g, VIII and IXa-k starting with bis(methylsulphanyl)methylenemalononitrile (V), which was reacted with phenylpiperazine and Na2S·9H2O to give the thioamide derivative VI. The latter was subjected to S-alkylation followed by Thorpe-Ziegler cyclization using commercially available phenacyl bromides, ethyl chloroacetate, and 2-chloroacetamides IVa-k to afford VIIa-g, VIII, and IXa-k, respectively |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anti-inflammatory |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Mitogen Activated Protein Kinase (MAPK) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thiophene |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala Bakr Elnassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Abdalla Khalil , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Elsayed Mohamed Elmeligie , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.Ph.D.2020.Ah.S | 01010110082585000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.Ph.D.2020.Ah.S | 01020110082585000 | 22.09.2023 | CD - Rom | 82585.CD |