Possible beneficial effects of benfotiamine, a thiamine derivative, in isoproterenol-induced myocardial infarction in rats / (Record no. 79825)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03082cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032703.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210207s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Om.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Omnia Farouk Abdelmonem Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Possible beneficial effects of benfotiamine, a thiamine derivative, in isoproterenol-induced myocardial infarction in rats / |
| Statement of responsibility, etc. | Omnia Farouk Abdelmonem Hassan ; Supervised Aiman Saad Elkhatib , Lamiaa Ahmed Ahmed , Omneya Osama Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المفيد المحتمل للبنفوتيامين: مشتق الثيامين: فى علاج إحتشاء عضلة القلب الناجم عن إيزوبروتيرينول فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Omnia Farouk Abdelmonem Hassan , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 134 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Acute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide.The present study was directed to investigate the beneficial effects of pre- and post-treatments with benfotiamine in isoproterenol (ISO)-induced MI in rats. Myocardial heart damage was induced by subcutaneous injection of ISO (150 mg/kg) once daily for two consecutive days. Benfotiamine (100 mg/kg/day) was given orally for two weeks before or after ISO treatment. ISO administration revealed significant changes in electrocardiographic recordings, elevation of levels of cardiac enzymes; creatinine kinase (CK-MB) and troponin-I (cTn-I), and perturbation of markers of oxidative stress; nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GPx) and markers of inflammation; protein kinase C (PKC), nuclear factor-kappa B (NF-{uF06B}B) and metalloproteinase-9 (MMP-9).The apoptotic markers (caspase-8 and p53) were also significantly elevated in ISO groups in addition to histological alterations. Groups treated with benfotiamine pre- and post-ISO administration showed significant decrease in cardiac enzymes levels and improvement of oxidative stress, inflammatory and apoptotic markers compared to the ISO groups. The current study highlights the potential role of benfotiamine as a promising agent for prophylactic and therapeutic interventions in myocardial damage in several cardiovascular disorders via NADPH oxidase inhibition |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute myocardial infarction (AMI) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Creatinine kinase (CK-MB) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | isoproterenol (ISO) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aiman Saad Elkhatib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Ahmed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Osama Galal , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Om.P | 01010110082722000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Om.P | 01020110082722000 | 22.09.2023 | CD - Rom | 82722.CD |