The potential anticonvulsant effect of flupirtine versus diazepam on experimentally induced epilepsy in mice and its interaction with celecoxib / (Record no. 79840)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03065cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032703.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210208s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2020.Ve.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Veronia Fawzy Fahim |
| 245 14 - TITLE STATEMENT | |
| Title | The potential anticonvulsant effect of flupirtine versus diazepam on experimentally induced epilepsy in mice and its interaction with celecoxib / |
| Statement of responsibility, etc. | Veronia Fawzy Fahim ; Supervised Soheir Aboelazm Diab , Mona Osman Abdelhalim , Noha Samir Abdellatif |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المضاد المحتمل للصرع للفلوبيريتين فى مقابل الديازيبام فى نموذج التشنجات المحدثة فى الفئران و تداخله مع السليكوكسيب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Veronia Fawzy Fahim , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 195 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: This study was designed to evaluate the anti-epileptic effect of flupirtine versus diazepam, as a monotherapy or in combination with celecxib,in models of generalized epilepsy and status epilepticus in mice. Materials and methods: Two models were applied; model A: pentylenetetrazole induced generalized seizures and model B: pilocarpine induced status epilepticus. Mice recieved: 1: normal saline,2: DMSO 10%, 3: diazepam, 4: flupirtine,5: celecoxib,6: combined diazepam & celecoxib,7: combined flupirtine & celecoxib. To score behavioral seizures and EEG changes,modified racine scale was used. Biochemical studies were done to measure brain GABA and IL-6 levels. Cresyl violet stain and GFAP immunohistochemistry were done to evaluate neuronal cell damage and glial responses respectively.Results: Diazepam and flupirtine prolonged latency period to 1st seizure. Diazepam showed better results than flupirtine in the pharmacological parameters, almost the same results in biochemical parameters, while flupirtine showed better histopathological results. The best results were found in the group receiving combined diazepam and celecoxib.Conclusion: Diazepam, flupirtine and celecoxib posses anticonvulsant, immuno-modulatory and neuroprotective effects.Flupirtine is a promising drug that could contribute to the control of generalized seizures and status epilepticus.Celecoxib- diazepam combination improves diazepam effect and thus this combination can be given in epileptic patients with other diseases that require treatment by anti-inflammatory drugs |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Epilepsy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Flupirtine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Racine scale |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Osman Abdelhalim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Samir Abdellatif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Soheir Aboelazm Diab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2020.Ve.P | 01010110082708000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2020.Ve.P | 01020110082708000 | 22.09.2023 | CD - Rom | 82708.CD |