Role of vitamin E on intestinal and renal autophagy (Gut {u2013} renal axis) in high fat - high fructose fed and endotoxemic rat models / (Record no. 79915)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03919cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032705.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210215s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2020.Ne.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Neamat Mahmoud Abdelgilil |
| 245 10 - TITLE STATEMENT | |
| Title | Role of vitamin E on intestinal and renal autophagy (Gut {u2013} renal axis) in high fat - high fructose fed and endotoxemic rat models / |
| Statement of responsibility, etc. | Neamat Mahmoud Abdelgilil ; Supervised Magda Mahmoud Elhamzawy , Nevien Mahmoud Mustafa , Asmaa Mohammed Shams Eldeen |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور فيتامين هـ فى الالتهام الذاتى للامعاء والكلى فى نماذج من الفئران مسممة الخلايا ومغذاة بنسبة عالية من الدهون والفركتوز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Neamat Mahmoud Abdelgilil , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 238 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and aims: Despite the plentiful researches that have been conducted to clarify the underling pathophysiology of the effect of HFD and fructose on the intestinal homeostasis and the disturbance of this homeostasis (dysbiosis) under septic conditions yet, there are a few studies which focused on the renal affection not only by the direct effect of both HFHF diet and sepsis but also through a gut-renal axis which depends on the leakage of endotoxins together with short chain fatty acids (SCFAs) which modulate renal functions. Autophagy and ER stress are cellular events which play fundamental roles in injury to keep the intestinal and renal homeostasis under stressful conditions.Thus, the main aim of the present study was to shed the light on the potential modulatory effects which are triggered by intestinaland renal ER stress on autophagic machinery in maintaining the intestinal homeostasis in response to HFHF over-nutrition especially under septic status and the impact of these modulations via the gut-renal axis on renal functions.The second objective in the study was to investigate the impact of vitamin E supplementation on these autophagy-mediated and ER-stress related modulations. Methods: Fifty four adult male albino rats were randomly allocated into three main experimental groups in addition to the control group for comparison. Each of the main groupswas subdivided as follows; Control group:which was subdivided into three subgroups ( control-diet , control-vehicle and control-drug i.e. vitamin E), High fat-high fructose (HFHF) fed groupwhich was subdivided into subgroups HFHF-V (vehicle-treated) and HFHF-E (Vitamin E-treated), septic group (LPS) which was subdivided into subgroups LPS-V (vehicle-treated) and LPS-E i.e. Vitamin E-treated and lastly combined group (HFHF+LPS)which was also subdivided into subgroups HFHF+LPS-V (vehicle-treated) and HFHF+LPS-E i.e. Vitamin E-treated).At the end of the experimental protocol, serum LPS and SCFAs, intestinal integrity markers (Occludin and ZO-1), renal functions (urea, creatinine, BUN and serum NGAL)and protein and gene expression of the inflammatory markers TLR4 , NF-kB were estimated.Autophagy and ER stress parameters (mTOR, Beclin, LC3) and (CHOP,XBP1, ATF4 and ATF6)respectively were also assessed in intestinal and renal tissues. In addition, the jejunal and renal architectures were assessed histologically |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Dysbiosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sepsis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vitamin E |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa Mohammed Shams Eldeen, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magda Mahmoud Elhamzawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevien Mahmoud Mustafa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2020.Ne.R | 01010110082768000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2020.Ne.R | 01020110082768000 | 22.09.2023 | CD - Rom | 82768.CD |