Effect of L- carnitine on cisplatin induced neuropathy and nephropathy in male albino rats / (Record no. 79930)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04016cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032705.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210217s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2020.Mo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Talal Hassan Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Effect of L- carnitine on cisplatin induced neuropathy and nephropathy in male albino rats / |
| Statement of responsibility, etc. | Mohamed Talal Hassan Mahmoud ; Supervised Hemmat Mohammed Ali Khloussy , Ahmed Desoky Badawy , Mohamed Mansour Khalifa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تاثير مادة ال- كارنيتين على وظائف الكلى و الاعصاب الطرفيه المتاثرة بعقار السيسبلاتين فى ذكور الجرذان البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Talal Hassan Mahmoud , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 181 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background & aim: cisplatin as antineoplastic drug belonging to platinum family has a severely nephrotoxic and neurotoxic side effects. L-carnitine (LC) is a natural compound with a nephro-protective and neuro-protective activity in several experimental studies. In the present study we have tested the hypothesis that LC may have a protective role on cisplatin induced nephropathy and neuropathy. Experimental Design: 48 male rats, 8 weeks old, their weight varies between 180 - 200 grams, randomly divided into 6 groups, each group included 8 rats. Control group. LC group received L- carnitine (250mg/kg body weight by daily intra-peritoneal injections for 3 days). Nephropathy group received single injection of cisplatin (20mg/kg body weight intra-peritoneal). Neuropathy group received daily intra {u2013} peritoneal injections of 2.3mg /kg body weight cisplatin within two rounds of 5 days with 5 {u2013} day break in between. LC Treated nephropathy group, L carnitine was injected IP after single injection of cisplatin for 3 days. LC Treated neuropathy group, L carnitine was injected IP after the second round of 5 days for 3 days On last day of experiment, serum levels of urea and creatinine were measured from each rat on the following groups (control group, LC group, nephropathy group and LC treated nephropathy group) then the rats were sacrificed by cerebral concussion and their kidneys were excised, weighted and processed for electron microscope for structural assessment. In addition, the distal end of rat tail of the following groups (control group, LC group, neuropathy group and LC treated neuropathy group) was immersed in hot water bath then latency for rat to withdrawal its tail was measured to assess the sensory affection of peripheral nerves then the right sciatic nerve was dissected and placed in moist chamber to be stimulated by power lab device for assessment of nerve conduction velocity and the amplitude of action potential Results: LC treatment after cisplatin injection was able to significantly reduce the nephrotoxicity and neurotoxicity of cisplatin in rat models. Serum urea and creatinine after treatment with LC were significantly reduced in comparison to the cisplatin group, in addition, LC treatment showed significantly increase in the physiological parameters of sciatic nerve. In conclusion: L-carnitine has a beneficial effect on improvement of neuropathy and nephropathy induced by cisplatin via its anti {u2013}oxidant effect and its ability to scavenge free oxygen radicals |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carnitine on cisplatin induced neuropathy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | L- carnitine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nephropathy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Desoky Badawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hemmat Mohammed Ali Khloussy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mansour Khalifa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2020.Mo.E | 01010110082848000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2020.Mo.E | 01020110082848000 | 22.09.2023 | CD - Rom | 82848.CD |