Clopidogrel versus ticagrelor in patients undergoing elective percutaneous coronary intervention with determination of plasma levels of both drugs using high performance liquid chromatography (HPLC) / (Record no. 80024)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03403cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032709.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210227s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.Ph.D.2020.Na.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nagwan Mahmoud Salama |
| 245 10 - TITLE STATEMENT | |
| Title | Clopidogrel versus ticagrelor in patients undergoing elective percutaneous coronary intervention with determination of plasma levels of both drugs using high performance liquid chromatography (HPLC) / |
| Statement of responsibility, etc. | Nagwan Mahmoud Salama ; Supervised Elsayed Mahmoud Elrokh , Ghada Mohamed Abdelzaher Hashim , Dina Ahmed Ali Labib |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | عقار الكلوبيدوجريل مقارنة بعقار التيكاجريلور فى مرضى القلب الخاضعين لقسطره القلب التداخليه العلاجيه مع تحديد نسبة العقارين فى البلازما باستخدام جهاز الكروماتوجرافيا السائله ذات الأداء العالى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Nagwan Mahmoud Salama , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 112 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and Objective: Recent guidelines consider percutaneous coronary intervention (PCI) with stent placement as a safe procedure in patients with stable coronary artery disease (SCAD) and it can improve the quality of life compared with the strategy of medical therapy. Oral anti-platelet agents, particularly aspirin in combination with ADP receptor blocker such as clopidogrel or ticagrelor constitute a cornerstone of therapy for these patients to reduce the risk of periprocedural and post-procedural ischemic events. To our knowledge, ticagrelor has not been well evaluated in elective PCI compared to clopidogrel, the currently recommended treatment Aim of the work: The aim of this work is to compare the clinical safety and efficacy of clopidogrel versus ticagrelor, as a part of dual anti-platelet therapy, in patients undergoing elective percutaneous coronary intervention with determination of actual plasma concentrations and the platelet inhibitory effect of both drugs by the help of ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and light transmission aggregometry (LTA) respectively. Methods: A total of 60 patients diagnosed with SCAD were enrolled in this study and scheduled for PCI. In addition to aspirin, half of the Patients received clopidogrel, 600 mg loading dose and 75mg daily thereafter. The other thirty patients received ticagrelor at a loading dose of 180mg and 90 mg twice daily thereafter. Detailed history of patients was taken before the PCI, including age, sex, BMI, presence of cardiovascular risk factors as hypertension, diabetes mellitus, hyperlipidemia, smoking, positive family history and medications on admission |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Clopidogrel |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SCAD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ticagrelor |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Ahmed Ali Labib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elsayed Mahmoud Elrokh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamed Abdelzaher Hashim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.Ph.D.2020.Na.C | 01010110082813000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.Ph.D.2020.Na.C | 01020110082813000 | 22.09.2023 | CD - Rom | 82813.CD |