Study on effect of dipeptidyl peptidase (DPP)-IV inhibitor on renal functions in rhabdomyolysis induced acute renal injury in rats / (Record no. 80047)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03420cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032709.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210228s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2020.Do.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Doaa Mostafa Elsayed |
| 245 10 - TITLE STATEMENT | |
| Title | Study on effect of dipeptidyl peptidase (DPP)-IV inhibitor on renal functions in rhabdomyolysis induced acute renal injury in rats / |
| Statement of responsibility, etc. | Doaa Mostafa Elsayed ; Supervised Samah Elattar , Nashwa Eltablawy , Shaimaa Nasr Amin |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسه عن تاثير مثبطات انزيم ثنائى البيبتيد الرابع على وظائف الكلى فى حالات الاصابه الحادة للكلى الناتجه عن انحلال العضلات المخططه فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Doaa Mostafa Elsayed , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 303 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Acute kidney injury (AKI) is a kind of acute dysfunction of the kidneys caused by various reasons in a short term, which usually leads to a serious disorder of the body{u2019}s internal environment. Rhabdomyolysis (RM) is considered to be one of the leading causes of AKI. Glycerol induced AKI is well-established animal model of rhabdomyolysis. There is accumulating evidence to suggest the potential benefits of DPP-IV inhibitor is in the setting of AKI. Aim of the work: Our study was designed to study the possible role of dipeptidyl peptidase DPP-IV inhibitor in modulating the pathogenic events related to rhabdomyolysis induced AKI in rats. It also compared between DPP-IV inhibitor and saline as the conventional treatment of AKI concerning their protective effects on AKI when used either separately or in combination and when used for different time intervals of the experiment (24 h and 72 h after injection of glycerol). Methods: Eighty male Albino rats were divided into 5 groups Group I: (control group), Group II; (AKI group), Group III;(AKI+ saline), Group IV;(AKI +sitagliptin 600 mg/kg/day), Group V; (AKI +sitagliptin+ saline), all groups of rats except the control group injected by 50% glycerol (10 ml/kg, i.m.) half dose in each hind limb muscle to induce AKI. All groups were divided into sub groups 8 rats each. Rat tail systolic blood pressure was measured either 24 h or 72 h after glycerol injection. Urine was collected separately for each rat, for 24 h for measurement of urine volume and urinary creatinine levels and GFR calculation. Blood samples were withdrawn retro-orbitally either at 24 h or 72 h after glycerol injection for measuring of serum creatinine, blood urea nitrogen, Na+, K+, creatine phosphokinase (CPK), Glucagon like peptide 1 (GLP1), TNF Ü, interleukin 10. Then 8 rats from each group were sacrificed either at 24 or72hours after injection of glycero |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | glycerol induced AKI |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute kidney injury |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rhabdomyolysis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nashwa Eltablawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samah Elattar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Nasr Amin , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2020.Do.S | 01010110082825000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2020.Do.S | 01020110082825000 | 22.09.2023 | CD - Rom | 82825.CD |