MARC details
| 000 -LEADER |
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| fixed length control field |
03467cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250223032711.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210306s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.09.Ph.D.2021.Ha.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Hanaa Mohamed Mahmoud Badawi |
| 245 10 - TITLE STATEMENT |
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| Title |
Investigation of the effect of bee venom in a model of parkinson{u2032}s disease in mice / |
| Statement of responsibility, etc. |
Hanaa Mohamed Mahmoud Badawi ; Supervised Ezz Eldin Said Eldinshery , Rania Mohsen Abdelsalam , Omar Mohamed Abdelsalam |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التحق{u٠٦أأ}ق فى تأث{u٠٦أأ}ر سم النحل فى نموذج من مرض الشلل الرعاش فى الفئران |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Hanaa Mohamed Mahmoud Badawi , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
163 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Objective(s): This study aimed to investigate the effect of bee venom, a form of alternative therapy, on rotenone-induced Parkinson{u2032}s disease (PD) in mice. Moreover, the possible modulation by bee venom of the effect of Ldopa/ carbidopa, bromocriptine or rasagiline was examined; also the pharmacological pathways of the effect of bee venom on the nitric oxide pathway using nitric oxide synthase inhibitors and the effect of cholinergic blockade using atropine were tested. Materials and Methods: Rotenone (1.5 mg/kg, subcutaneously; s.c.) was administered every other day for two weeks and at the same time mice received the vehicle (DMSO, s.c.), bee venom (0.065, 0.13 and 0.26 mg/kg; intradermal; i.d.), L-dopa/carbidopa (25 mg/kg, intraperitoneal; i.p.), Ldopa/ carbidopa + bee venom (0.13 mg/kg, i.d.), bromocriptine (1.5mg/kg mice, i.p.), bromocriptine (1.5mg/kg mice, i.p.) + bee venom (0.13 mg/kg, i.d.), rasagiline (1 mg/kg, i.p.), rasagiline + bee venom (0.13 mg/kg, i.d.), LNAME (10mg/kg mice, i.p.) + bee venom (0.13mg/kg, i.d.), 7-nitroindazole (10 mg/kg mice, i.p.) + bee venom (0.13mg/kg, i.d.) and atropine (1mg/kg mice, i.p.) + bee venom (0.13mg/kg, i.d.). Then, wire hanging and staircase tests were performed and mice were euthanized and brains{u2032} striata separated. Oxidative stress biomarkers namely, malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), paraoxonase-1 (PON-1) and total antioxidant capacity (TAC) were measured. Additionally, butyrylcholinesterase (BuChE), monocyte chemoattractant protein-1 (MCP- 1), tumor necrosis factor-alpha (TNF-Ü) and dopamine (DA) were evaluated. Brain histopathological changes and caspase-3- expression were examined Results: Bee venom significantly enhanced motor performance and inhibited rotenone-induced oxidative/nitrosative stress, observed as a reduction in both MDA and NO along with increasing GSH, PON-1, and TAC. Besides, bee venom decreased MCP-1, TNF-Ü and caspase-3 expression together with an increase in BuChE activity and DA content |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Bee venom |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Mice |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Model of parkinson{u2032}s disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ezz Eldin Said Eldinshery , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Omar Mohamed Abdelsalam , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Rania Mohsen Abdelsalam , |
| Relator term |
|
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
