The effect of mesenchymal stem cell derived extracellular vesicles on ciRS-7 in treatment of experimentally induced Parkinson{u2019}s disease in rats / (Record no. 80239)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03593cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032715.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210314s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.M.Sc.2020.He.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hend Ayman Ali Habiba |
| 245 14 - TITLE STATEMENT | |
| Title | The effect of mesenchymal stem cell derived extracellular vesicles on ciRS-7 in treatment of experimentally induced Parkinson{u2019}s disease in rats / |
| Statement of responsibility, etc. | Hend Ayman Ali Habiba ; Supervised Dina Sabry Abdelfattah , Mai Abdelaziz Gouda , Heba Abdelmonem Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى علاج مرض الشلل الرعاش في فئران التجارب ciRS-7 دراسة تأثير الحويصلات الدقيقة المستخلصة من الخلايا الجذعية المزنشيمية على الحمض النووى الريبوزى المستدير |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hend Ayman Ali Habiba , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 138 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Parkinson{u2019}s disease is a neurodegenerative disease that leads to loss of dopaminergic neurons in the substantia nigra of the midbrain, as well as alpha-synuclein protein accumulation. Levodopa combined with carbidopa is the standard treatment. Mesenchymal stem cell (MSC) derived extracellular vesicles (exosomes) are now widely tested for their regenerative and therapeutic effects in many diseases. We aimed to investigate the role of ciRS-7 in treatment of Parkinson{u2019}s disease by MSC-derived EVs (exosomes). Methods: The experiment was done on thirty-two white albino rats grouped as follows, group (1): eight healthy rats as normal control, group (2) eight experimentally induced Parkinson{u2019}s disease rats, group (3): eight experimentally induced Parkinson{u2019}s disease rats received levodopa/carbidopa orally, and group (4): eight experimentally induced Parkinson{u2019}s disease rats received MSC derived EVs (exosomes) intranasally. Brain tissue alpha-synuclein was assessed by ELISA. Quantitative RT-PCR was done to assess regeneration of midbrain tissue by measuring miR-7 and ciRS-7 gene expression. Additionally, histopathological and immune-histochemical examinations were done to confirm dopaminergic neuron regeneration. Results: In the treated groups either with EVs (exosomes) or levodopa/carbidopa, regenerative results were achieved but were more significant in EVs (exosomes) treated group. There was a significant decrease in brain tissue alpha-synuclein in levodopa/carbidopa and EVs (exosomes) treated groups compared to Parkinson{u2019}s disease group (p value =0.006 and <0.0001 respectively). Regarding the assessed genes (ciRS-7 and miR-7) there was a significant decrease in gene expression of ciRS-7 in the levodopa/carbidopa treated group compared to Parkinson{u2019}s disease group (p value<0.0001) and in the EVs (exosomes) treated group compared to Parkinson{u2019}s disease and levodopa/carbidopa treated groups (p value<0.0003 and p value = 0.046 respectively) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ciRS-7 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Parkinson{u2019}s disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfattah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Abdelmonem Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Abdelaziz Gouda , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.M.Sc.2020.He.E | 01010110083047000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.M.Sc.2020.He.E | 01020110083047000 | 22.09.2023 | CD - Rom | 83047.CD |