MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03017cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210315s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2020.Ma.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maha Mohamed Abdullah Mahmoud |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Formulation of nanocarriers for improvement of bioavailability of an antihypertensive drug : |
| Remainder of title |
A pharmaceutical study / |
| Statement of responsibility, etc. |
Maha Mohamed Abdullah Mahmoud ; Supervised Emad Basalious Besheir , Abeer Moustafa Khattab |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
صياغة حوامل متناهية الصغر لتحسين الحيوية لأحد العقاقير المضادة لارتفاع ضغط الدم : |
| Remainder of title |
دراسة صيدلية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Maha Mohamed Abdullah Mahmoud , |
| Date of publication, distribution, etc. |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
109 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Aliskiren- hemifumarate (AF) is non-peptide direct renin inhibitor used as antihypertensive drug. Renin is secreted by kidney and cleaves its substrate, angiotensinogen, forming the inactive decapeptide (Ang I) that is converted to an active octapeptide (Ang II) by angiotensin converting enzyme (ACE). Ang II is a powerful vasoconstrictor, enhances catecholamine release from adrenal medulla, and promotes aldosterone secretion and sodium reabsorption. All the currently available agents that inhibit the renin system stimulate compensatory renin release from the kidney, which results in an increase in plasma renin activity (PRA) that may ultimately lead to increased levels of Ang II, So targeting the renin system at its point of activation by directly inhibiting renin activity has therefore long been proposed as the optimal means of suppressing the renin system. Despite its potency as antihypertensive drug, its bioavailability is very poor (about 2.5%) which explained by its high solubility and poor permeability. Aliskiren is administered in market in a dose 150-300 mg but for high drug cost, the amount of drug in the prepared formulations ranged from 25-50 mg. The goal of this thesis is to enhance oral bioavailability of aliskiren.The work is divided into three chapters as follows: Chapter I: Preparation and Characterization of Aliskiren- loaded Transferosomal Vesicles Chapter II: Preparation and Characterization of Aliskiren- loaded Self Nanoemulsifying System (SNES) Chapter III: Preparation and Characterization of a SNENVS Formulation and Bioequivalence Study of the SNENVS Formulation and the Marketed Tablet |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Bioavailability of an antihypertensive drug |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nanocarriers for improvement |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nngiotensin converting enzyme (ACE) |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abeer Moustafa Khattab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Emad Basalious Besheir , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
