Synthesis, modifications and characterization of chitosan derivatives based on heterocyclic compounds / (Record no. 80331)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03462cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032718.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210322s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2021.Am.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amira Ahmed Hamed Swelam |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis, modifications and characterization of chitosan derivatives based on heterocyclic compounds / |
| Statement of responsibility, etc. | Amira Ahmed Hamed Swelam ; Supervised Ismail Abdelshafy Abdelhamid , Maher Zaki Elsabee , Gamal Riad Saad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير وتحوير وتوصيف مشتقات الكيتوزان المبنية على مركبات حلقية غير متجانسة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amira Ahmed Hamed Swelam , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 195 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Three heteroaryl pyrazole derivatives; namely: 1-phenyl-3-(thiophene-2-yl)-1H-pyrazole-4-carbaldehyde,1-phenyl-3-(furan-2-yl)-1H-pyrazole-4-carbaldehyde, 1-phenyl-3-(pyridine-3-yl)-1H-pyrazole-4-carbaldehyde were synthesized. In addition, some Cs-Schiff bases containing thiophene, furan and pyridyl nucleus have been synthesized. Characterizations of the prepared compounds via FTIR ¹ H NMR, elemental analysis, X-ray diffraction, SEM, and TGA were carried out. The prepared Cs-Schiff bases were screened for their biological activity against gram-negative bacteria (Escherichia coli and Klebsiella pneumonia), gram-positive bacteria (Staphylococcus aureus and Streptococcus mutans) and fungi (Aspergillus fumigatus and Candida albican). Preliminary cytotoxicity tests were performed using MTT assay with normal retina cell line. Besides, the prepared Cs-Schiff-bases loaded with different contents of silver nanoparticles (AgNPs) have been synthesized, characterized and preliminary evaluated as Schistosomacidal activity agents. Finally, partially cross-linked chitosan Schiff bases have been synthesized using bis-aldehydes, namely butane-1,4-diyl bis(4-formylbenzoate), N,N'-(butane-1,4-diyl)bis(2-(4-formylphenoxy)acetamide) and 4,4{u2032}-(butane-1,4-diylbis(oxy))dibenzaldehyde. The influence of the type and the amount of used bis-aldehyde and pH of the media on the swelling of the prepared chitosan derivatives was investigated. It was found that the extent of swelling of the chitosan derivative increased with increasing the extent of crosslinking, contrary to the expectation. The loading efficacy of sodium salicylate (SS), as a model of drug, and its release behavior from these derivatives at pH of the media 4.0 and 7.4 were tested. The results showed that the loading efficiency and encapsulation were slightly dependent on the type of cross-linking agent. In vitro, SS release behavior showed that the release was affected by pH of the media and type of the bis-aldehyde crosslinker |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antimicrobial and schistosomacidal activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chitosan Schiff bases bearing heterocyclic rings |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Schiff bases/silver nanoparticles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gamal Riad Saad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maher Zaki Elsabee , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2021.Am.S | 01010110083017000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2021.Am.S | 01020110083017000 | 22.09.2023 | CD - Rom | 83017.CD |