MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02897cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210322s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.06.Ph.D.2021.Sh.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shahira Abdelsalam Elbanna |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Investigation of the potential role of toxin-antitoxin systems in virulence and antimicrobial resistance in some gram-negative bacteria / |
| Statement of responsibility, etc. |
Shahira Abdelsalam Elbanna ; Nayera Ahmed Moneib , Ramy Karam Aziz , Reham Samir Mohamed |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التحقق من تأثير أنظمة السموم ومضاداتها على ضراوة البكتيريا سالبة الجرام ودورها فى مقاومة المضادات الحيوية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shahira Abdelsalam Elbanna , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
77 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Toxin-antitoxin (TA) systems are widespread among bacteria, archaea and fungi. They play different roles, such as postsegregational killing, abortive infection, and persister cell formation, and have recently been proposed as novel drug targets. TA systems are classified into six types (I-VI), based on the nature of antitoxin and its mode of action. This workaimed to screen the pathogen Acinetobacter baumannii, known for its alarming antimicrobial resistance, for TA systems, and to identify a CptBA-like Type IV TA, one of the least characterized systems. Comparative genomics demonstrated the distribution of E. coliCptBA-like systems among Gram-negative bacteria, while phylogenetic analysis of CptA and CptBdelineated two major groups, in each of which Acinetobacter spp. clustered together. Multiple sequence alignment indicated the conservation of cptA and cptB in 195 strains of A. baumannii in the same syntenic order. Using A. baumannii recombinant cptA and cptB, cloned under different promoters, confirmed thetoxin-antitoxin nature of their encoded proteins, as cptB expression was able to reverse growth inhibition by CptA in a dose-time-dependent manner.Furthermore, transcriptional analysis of cptBA in its natural bacterial host (A. baumannii) demonstrated that the cptBA locus is actively co-transcribed under normal conditions; yet, their transcriptional levels were reduced under oxidative and antibiotic stress, including ciprofloxacin and meropenem |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Acinetobacter baumannii |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Antimicrobial resistance |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Toxin antitoxin system |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nayera Ahmed Moneib , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ramy Karam Aziz , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Reham Samir Mohamed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
