Relationship of apolipoprotein E gene Polymorphisms to Idiopathic Parkinson{u2019}s Disease / (Record no. 80466)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03111cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210401s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.20.Ph.D.2020.He.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Assem Deraz |
| 245 10 - TITLE STATEMENT | |
| Title | Relationship of apolipoprotein E gene Polymorphisms to Idiopathic Parkinson{u2019}s Disease / |
| Statement of responsibility, etc. | Heba Assem Deraz ; Supervised Ebtisam Mohamed Fahmy , Amany Mahmoud Rabah , Laila Ahmed Rashed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | العلاقة بين تعدد الأشكال الجينية للابوليبوبروتين إ و داء باركنسون المجهول السبب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Heba Assem Deraz , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 144 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Neurosurgery |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Research focusing on the role of Apolipoprotein E (APOE) in Parkinson{u2019}s disease (PD) has been largely inconclusive, creating a broad discrepancy in association studies. Objective: To study the association between serum APOE level and APOE gene polymorphisms and idiopathic Parkinson{u2019}s disease. Subjects and Methods: Fifty-five patients with idiopathic PD and thirty healthy subjects were enrolled. Disease severity was assessed using Unified Parkinson{u2019}s Disease Rating Scale (UPDRS), Modified Hoehn and Yahr (HY) scale, and Schwab-England Activities of Daily Living scale. All participants were genotyped for APOE polymorphisms using polymerase chain reaction (PCR). Serum APOE level was also measured using enzyme-linked immunosorbent assay (ELISA). Results: Mean serum APOE level was significantly higher in PD patients compared to healthy controls. APOE f2/4 genotype was present in a significantly higher proportion in patients with PD compared to controls, however, no significant difference was found in the distribution of other APOE genotypes or APOE alleles between the two groups. f4 allele was significantly associated with a higher score on the {u2018}mentation, behavior, and mood section{u2019} of UPDRS compared to f2 allele. APOE f2 allele was significantly associated with a shorter disease duration compared to f3 and f4 alleles. Mean serum APOE level was significantly higher in patients presenting by predominant rigidity and bradykinesia compared to patients presenting by predominant tremors, but nodifference was found regarding the distribution of APOE genotypes. A significant positive correlation was found between serum APOE level and mean scores of {u2018}mentation, behavior, and mood section{u2019} of UPDRS, but not with the rest of PD rating scales mean scores |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apolipoprotein E |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Genotyping |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Parkinson{u2019}s disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amany Mahmoud Rabah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ebtisam Mohamed Fahmy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.20.Ph.D.2020.He.R | 01010110083119000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.20.Ph.D.2020.He.R | 01020110083119000 | 22.09.2023 | CD - Rom | 83119.CD |