Design, Synthesis and Cytotoxicity of Novel Thiophene, Azole, Azine and their fused derivative / (Record no. 80469)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02582cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032722.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210401s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.Ph.D.2020.Re.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Mohammed Abdelkadir |
| 245 10 - TITLE STATEMENT | |
| Title | Design, Synthesis and Cytotoxicity of Novel Thiophene, Azole, Azine and their fused derivative / |
| Statement of responsibility, etc. | Reem Mohammed Abdelkadir ; Supervised Rafat M. Mohareb |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتحضير وقياس السمية لمركباث الثيوفين والأزول والأزينات ومشتقاتها الملتحمة الجديدة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Mohammed Abdelkadir , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 247 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The 1-(1H-benzo[d]imidazol-2-yl)propan-2-one (3) and the ethyl 2-(1Hbenzo[ d]imidazol-2-yl)acetate (16) were used as the key starting material which reacted with salicylaldehyde to give the corresponding benzo[4,5]imidazo[1,2-a]quinoline derivatives. On the other hand, both of them were reacted with different reagents to give thiophene, pyran and benzo[4,5]imidazo[1,2-c]pyrimidine derivatives. The synthesized compounds were evaluated against the six cancer cell linesA549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460 using the standard MTT assay in vitro, with foretinib as the positive control, many compounds expressed high inhibitions. Compounds 3, 5b, 10b, 12a, 12b, 16, 18, 19a, 19b and 21 were the most cytotoxic compounds toward the six cancer cell lines This work demonstrated multicomponent reactions of cyclohexan-1,3- dione with aromatic aldehydes and diethylmalonate to give the the 7,8- dihydro-4H-chromen-5(6H)-one derivatives 4a-c). The reaction of compounds 4a-c with either of hydrazine hydrate of phenylhydrazine gave the chromeno[2,3-c]pyrazole derivatives 5a-f, respectively. In addition further heterocyclization reactions were adopted to give the chromeno[3,2- d]isoxazole, chromene-3-carboxamide derivatives. Moreover, the multicomponent reaction of cyclohexan-1,3-dione (1) with either of aromatic |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclohexan-1,3-dione |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hexahydroquinoline |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multi-component reactions |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat M. Mohareb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.Ph.D.2020.Re.D | 01010110083121000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.Ph.D.2020.Re.D | 01020110083121000 | 22.09.2023 | CD - Rom | 83121.CD |