MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02542cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210412s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.Ph.D.2021.Sh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shaymaa Elsayed Khater Elsayed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Pharmaceutical study on fluoxetine hydrochloride nanocarriers / |
| Statement of responsibility, etc. |
Shaymaa Elsayed Khater Elsayed ; Supervised Dalia Mahmoud Mohamed Ghorab , Abdulaziz Mohsen Almahallawi , Hend Mohamed Abdelbar |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة صيدلية على حاملات نانومتريه للفلوكستين هيدروكلوريد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shaymaa Elsayed Khater Elsayed , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
160 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Firstly, the study investigates the feasibility of hexosomes (HEX) as a competent platform for fluoxetine hydrochloride (FH) repurposing against HepG2 hepatocellular carcinoma. Different FH-loaded HEX formulations were prepared and optimized by the hot emulsification method. The HEX features as particle size, zeta potential, and drug entrapment efficiency (EE %) can be tailored by tuning HEX components and fabrication conditions. The composition of the optimized FH hexosomes (OFH-HEX) was 3.1, 1.4, 0.5, 0.2, and 94.8% for glyceryl monooleate, oleic acid, pluronic F127, FH, and deionized water respectively. The anionic OFH-HEXwith a particle size of 145.5±2.5 nm and drug EE % of 45.4±1.2% was able to prolong in vitro FH release where only 19.5±2.3% released in PBS pH7.4 after 24 h. Contrarily, HEX rapidly released FH in acetate buffer pH5.5 and achieved a 90.5±4.7% release after 24 h which facilitates the passive targeting of FH to the cancer cells. Moreover, the obtained HEX showed an improved cellular internalization in a time-dependent manner and enhanced cytotoxicity (2-fold higher than FH solution). Consequently, this chapter suggests the potential of FH-HEX as a possible anticancer agent against hepatocellular carcinoma |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Fluoxetine hydrochloride |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Hexosomes |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Repurposing |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abdulaziz Mohsen Almahallawi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dalia Mahmoud Mohamed Ghorab , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hend Mohamed Abdelbar , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
