MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03474cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
210414s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.M.Sc.2021.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Samar Mamdouh Mohamed Shawki |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A study of the possible curative effect of Liraglutide {u2013} a Glucagon-like Peptide -1 analog - on cognitive deficits in 3-Nitropropionic acid {u2013}Induced Huntington{u2019}s Disease in rats / |
| Statement of responsibility, etc. |
Samar Mamdouh Mohamed Shawki ; Supervised Hanan S. Eabhar , Walaa Wadie Ibrahim , Rania Mohammed Rahmo |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة عن التأثير العلاجى المحتمل لنظير الببتيد الشبيه بالجلوكاجون -1:ليراجلوتايد فى نموذج مرض هنتنغتون المحدث تجريبيا بواسطة حمض3- النيتروبروبيونيك فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Samar Mamdouh Mohamed Shawki , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
130 P . : |
| Other physical details |
charts , facsmilies ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Introduction: Huntington{u2019}s disease (HD) is a dominant autosomal neurodegenerative disease associated with progressive motor and cognitive deficits that lacks a definitive symptomatic therapy. The antidiabetic liraglutide possesses a neuroprotective potential against models of neurodegenerative disorders; however, its role in HD remains elusive which is the aim of this work. Methods: Liraglutide (200 og/kg, s.c) was administered to rats intoxicated with 3-nitropropionic acid (3-NP) for 4 weeks post HD model induction. Results: Liraglutide abated the 3-NP-induced neurobehavioral deficits tested by open field and elevated plus maze tests, effects that were mirrored on the improved histopathological findings. To further emphasize its neuroprotective role, liraglutide markedly downregulated the striatal mRNA expression of HSP 27, PBR and GFAP, while it upregulated that of DARPP32. On the molecular level, liraglutide enhanced striatal miR-130a gene expression and TrKB protein expression and its ligand BDNF, while reduced the striatal protein content and mRNA expression of the death receptors sortilin and p75NTR, respectively. Additionally, it enhanced the neuroprotective molecules cAMP, p-PI3K, p-Akt and p-CREB, besides modulating the p-GSK-3Ý/p-Ý-catenin axis. Liraglutide also proved its anti-oxidant/-apoptotic capacity that were verified by enhancing the antioxidant transcription factor Nrf2 and abrogating MDA, besides, upregulating both Bcl2 and Bcl-XL and downregulating Bax along with decreasing caspase-3 activity. Conclusion: based on these findings, liraglutide exerts a neuroprotective effect on 3-NP treated rats that is at least partially attributed to the increase of miR-130a and modulation of PI3K/Akt/CREB/BDNF/TrKB, sortilin and p75NTR, and Akt/ GSK-3Ý/p-Ý-catenin trajectories besides its anti-apoptotic, antioxidant, and neurotrophic activities |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
3-nitropropionic acid |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
BDNF/TrkB |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Huntington{u2019}s disease |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanan S. Eabhar, |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Rania Mohammed Rahmo , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Walaa Wadie Ibrahim , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Amira |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
