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Possible effects of certain natural products on thioacetamide-induced hepatotoxicity in rats / (Record no. 80653)

MARC details
000 -LEADER
fixed length control field 03375cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223032728.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210415s2021 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.08.09.Ph.D.2021.Ay.P
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Ayah Mohamed Hany Elsayed
245 13 - TITLE STATEMENT
Title Possible effects of certain natural products on thioacetamide-induced hepatotoxicity in rats /
Statement of responsibility, etc. Ayah Mohamed Hany Elsayed ; Supervised Sanaa Abdelbaky Kenawy , Somaia Ahmed Nada , Marwa Mohammed Safar
246 15 - VARYING FORM OF TITLE
Title proper/short title التأثيرات الممكنة لمنتجات طبيعية معينة فى التسمم الكبدى المحدث بواسطة الثيوأسيتاميد فى الجرذان
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Ayah Mohamed Hany Elsayed ,
Date of publication, distribution, etc. 2021
300 ## - PHYSICAL DESCRIPTION
Extent 208 P . :
Other physical details charts , facsmilies ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
520 ## - SUMMARY, ETC.
Summary, etc. Protection against liver injury and its consequences is considered an essential issue to minimize the number of annual deaths caused by liver diseases. The present study was designed to evaluate the potential role of pomegranate peel extract (PPE) and/or curcumin, compared to silymarin in regression of thioacetamide (TAA)-induced liver injury, focusing on their modulatory effects on TGF-Ý/Smad3 and NF-mB signaling pathways. Hepatotoxicity was induced in adult male Wistar rats by intraperitoneal injection of TAA (100 mg/kg) three times a week, for 8 weeks. To assess the protective effects of PPE and/or curcumin against TAA-induced hepatotoxicity, compared to silymarin, rats were treated on a daily basis with oral doses of silymarin (50 mg/kg), curcumin (200 mg/kg), PPE (200 mg/kg), or a combination of PPE and curcumin, respectively for 8 weeks. The results indicated that treatment with silymarin, curcumin, PPE, or the combined therapy attenuated TAA-induced liver injury, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, total bilirubin, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-{u0138}B, TNF-Ü, IL-1Ý, iNOS, TGF-Ý, and MPO), compared to TAA group. Moreover, administration of silymarin, curcumin, PPE, or the combined therapy exerted a significant downregulation of phospho-Smad3 protein expression; Ü-SMA, TIMP-1, and collagen-1 gene expressions, as well as significant reduction in liver Hyp content. The macroscopical, histopathological, and histochemical examinations have corroborated these findings. In conclusion, hepatoprotective activities of silymarin, curcumin, PPE, or the combined therapy could be linked to their abilities to modulate NF-mB, and TGF-Ý/Smad3 signaling pathways. It is worth noting that the combination of PPE and curcumin exerted superior hepatoprotective effects against TAA-induced liver injury, compared to monotherapy
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Curcumin
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Silymarin
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Thioacetamide
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Marwa Mohammed Safar,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Sanaa Abdelbaky Kenawy ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Somaia Ahmed Nada ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Amira
Reviser Cataloger
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.08.09.Ph.D.2021.Ay.P 01010110083265000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.08.09.Ph.D.2021.Ay.P 01020110083265000 22.09.2023 CD - Rom 83265.CD