Possible effects of certain natural products on thioacetamide-induced hepatotoxicity in rats / (Record no. 80653)
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000 -LEADER | |
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fixed length control field | 03375cam a2200349 a 4500 |
003 - CONTROL NUMBER IDENTIFIER | |
control field | EG-GiCUC |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20250223032728.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 210415s2021 ua dh f m 000 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | EG-GiCUC |
Language of cataloging | eng |
Transcribing agency | EG-GiCUC |
041 0# - LANGUAGE CODE | |
Language code of text/sound track or separate title | eng |
049 ## - LOCAL HOLDINGS (OCLC) | |
Holding library | Deposite |
097 ## - Thesis Degree | |
Thesis Level | Ph.D |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
Classification number | Cai01.08.09.Ph.D.2021.Ay.P |
100 0# - MAIN ENTRY--PERSONAL NAME | |
Personal name | Ayah Mohamed Hany Elsayed |
245 13 - TITLE STATEMENT | |
Title | Possible effects of certain natural products on thioacetamide-induced hepatotoxicity in rats / |
Statement of responsibility, etc. | Ayah Mohamed Hany Elsayed ; Supervised Sanaa Abdelbaky Kenawy , Somaia Ahmed Nada , Marwa Mohammed Safar |
246 15 - VARYING FORM OF TITLE | |
Title proper/short title | التأثيرات الممكنة لمنتجات طبيعية معينة فى التسمم الكبدى المحدث بواسطة الثيوأسيتاميد فى الجرذان |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Cairo : |
Name of publisher, distributor, etc. | Ayah Mohamed Hany Elsayed , |
Date of publication, distribution, etc. | 2021 |
300 ## - PHYSICAL DESCRIPTION | |
Extent | 208 P . : |
Other physical details | charts , facsmilies ; |
Dimensions | 25cm |
502 ## - DISSERTATION NOTE | |
Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Protection against liver injury and its consequences is considered an essential issue to minimize the number of annual deaths caused by liver diseases. The present study was designed to evaluate the potential role of pomegranate peel extract (PPE) and/or curcumin, compared to silymarin in regression of thioacetamide (TAA)-induced liver injury, focusing on their modulatory effects on TGF-Ý/Smad3 and NF-mB signaling pathways. Hepatotoxicity was induced in adult male Wistar rats by intraperitoneal injection of TAA (100 mg/kg) three times a week, for 8 weeks. To assess the protective effects of PPE and/or curcumin against TAA-induced hepatotoxicity, compared to silymarin, rats were treated on a daily basis with oral doses of silymarin (50 mg/kg), curcumin (200 mg/kg), PPE (200 mg/kg), or a combination of PPE and curcumin, respectively for 8 weeks. The results indicated that treatment with silymarin, curcumin, PPE, or the combined therapy attenuated TAA-induced liver injury, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, total bilirubin, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-{u0138}B, TNF-Ü, IL-1Ý, iNOS, TGF-Ý, and MPO), compared to TAA group. Moreover, administration of silymarin, curcumin, PPE, or the combined therapy exerted a significant downregulation of phospho-Smad3 protein expression; Ü-SMA, TIMP-1, and collagen-1 gene expressions, as well as significant reduction in liver Hyp content. The macroscopical, histopathological, and histochemical examinations have corroborated these findings. In conclusion, hepatoprotective activities of silymarin, curcumin, PPE, or the combined therapy could be linked to their abilities to modulate NF-mB, and TGF-Ý/Smad3 signaling pathways. It is worth noting that the combination of PPE and curcumin exerted superior hepatoprotective effects against TAA-induced liver injury, compared to monotherapy |
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
Additional physical form available note | Issued also as CD |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | Curcumin |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | Silymarin |
653 #4 - INDEX TERM--UNCONTROLLED | |
Uncontrolled term | Thioacetamide |
700 0# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Marwa Mohammed Safar, |
Relator term | |
700 0# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sanaa Abdelbaky Kenawy , |
Relator term | |
700 0# - ADDED ENTRY--PERSONAL NAME | |
Personal name | Somaia Ahmed Nada , |
Relator term | |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
Cataloger | Amira |
Reviser | Cataloger |
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
Cataloger | Nazla |
Reviser | Revisor |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | Dewey Decimal Classification |
Koha item type | Thesis |
Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
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Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2021.Ay.P | 01010110083265000 | 22.09.2023 | Thesis | ||
Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2021.Ay.P | 01020110083265000 | 22.09.2023 | CD - Rom | 83265.CD |