Short term effect of vitamin D administrationon the clinical outcomes in patients undergoing valve replacement surgery / (Record no. 80688)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03807cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210418s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2021.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sandra Nael Naguib Wahba |
| 245 10 - TITLE STATEMENT | |
| Title | Short term effect of vitamin D administrationon the clinical outcomes in patients undergoing valve replacement surgery / |
| Statement of responsibility, etc. | Sandra Nael Naguib Wahba ; Supervised Samar F. Farid , Nirmeen A. Sabry , Adel Mohamad Alansary |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تأثير تناول فيتامين (د) على المدى القصير على النتائج الإكلينيكية فى المرضى الذين يخضعون لجراحة استبدال الصمام |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sandra Nael Naguib Wahba , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The discovery that most body tissues express vitamin D receptors, has provided new insights to the biological activity of vitamin D. Many recent studies have found a positive association between vitamin D deficiency and worse clinical outcomes in critically-ill patients. Patients undergoing open-heart surgeries are at higher risk due to the associated life-threatening postoperative complications. The suggested beneficial effects of active vitamin D on the cardiovascular system, immune functions, and wound healing could be of particular interest in critically-ill patients, especially those undergoing valve replacement surgery. Objective: This study was conducted to determine and to compare the effect associated with alfacalcidol supplementation versus control on the overall post-cardiac surgery clinical parameters. The primary outcomes were length of stay in intensive care unit and in hospital. Secondary outcomes were the incidence of postoperative hospital acquired infections, cardiac complications, and in-hospital mortality. Methods: This is a randomized, open-label, controlled, single center trial, conducted at the Cardiovascular and Thoracic Academy, Ain Shams University, from April 2017 to January 2018. This study included 89 adult patients undergoing valve replacement surgery who were randomized to the control group (n = 42) or to the intervention group (n = 47) assigned to daily 2 mcg of alfacalcidol started two to four days before operation and continued throughout the hospital stay. Blood samples were withdrawn at the following time points: T1) immediately before alfacalcidol first dose administration (baseline); T2) 48 hours post-surgery; T3) 4 days post-ICU discharge. At each time point, serum levels of 25-hydroxyvitamin D, total calcium, phosphorous, kidney functions, liver functions, hemoglobin, platelet and white blood cells count were assessed. Incidence of postoperative complications were also evaluated daily during the hospital stay. Results: A total of 86 patients were included in the final analysis with 51 (59.3%) patients being vitamin D deficient on hospital admission. Treatment with alfacalcidol resulted in a statistically significant decrease in the intensive care unit length of stay (ICU LOS) (Hazard ratio = 1.61, 95% confidence interval = 1.77{u2013}2.81, P = 0.041) and hospital length of stay (LOS) (Hazard ratio = 1.63, 95% confidence interval = 1.04{u2013}2.55, P= 0.034) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alfacalcidol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Critical care |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vitamin D |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Adel Mohamad Alansary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nirmeen A. Sabry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samar F. Farid , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2021.Sa.S | 01010110083283000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2021.Sa.S | 01020110083283000 | 22.09.2023 | CD - Rom | 83283.CD |