Novel diaryl urea based compounds : (Record no. 80724)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02470cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032730.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210421s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.04.Ph.D.2021.Ma.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mohamed Mohamed Ahmed Sharaky |
| 245 10 - TITLE STATEMENT | |
| Title | Novel diaryl urea based compounds : |
| Remainder of title | Mechanistic study and anticancer biological evaluation / |
| Statement of responsibility, etc. | Marwa Mohamed Mohamed Ahmed Sharaky ; Supervised Monira Mohamed Rageh , Samia Abdelsamieh Shouman , Khaled Abouzid Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسه اليه و تقييم بيولوجى كمضادات للسرطان : |
| Remainder of title | مركبات ثنائى مشتقات الفنيل يوريا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Mohamed Mohamed Ahmed Sharaky , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 2016 P . : |
| Other physical details | charts,facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biophysics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Breast cancer is the most common cancer diagnosed in women. Tamoxifen (TAM) is the gold standard in therapy of estrogen receptor positive breast cancer (ER+ BC), however its efficacy is challenged by acquired resistance. Angiogenesis plays fundamental roles in TAM resistance where VEGFR-2 is a key player in this process. Thus, targeting of VEGFR-2 signaling pathway has been an attractive approach for BC therapy. In this study, we synthesized a new thieno[2,3-d]pyrimidine based urea derivative KM6, which exhibited potential antitumor activity in both TAM-sensitive MCF7 and TAM-resistant LCC2 BC cells. In addition to its antiangiogenic properties, KM6 retained the sensitivity of LCC2 via modulation of key proteins and enzymes of apoptosis and cell death (caspases 3,8,9, survivin, P53, BAX, BCL-2, LDH) and ROS. Moreover, KM6 modulated vital biological markers of inflammation (PGE2, COX2, IL-1Ý and IL6) and metastasis (MMP-2 and MMP-9). Thus, KM6 is a promising compound for ER+ and TAM-resistant BC with polypharmacological properties |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thieno[2,3-d]pyrimidine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | VEGFR-2 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Abouzid Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Monira Mohamed Rageh , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Abdelsamieh Shouman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.04.Ph.D.2021.Ma.N | 01010110083306000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.04.Ph.D.2021.Ma.N | 01020110083306000 | 22.09.2023 | CD - Rom | 83306.CD |