MARC details
| 000 -LEADER |
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| fixed length control field |
03907cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20250223032731.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210424s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
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| Holding library |
Deposite |
| 097 ## - Thesis Degree |
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| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Classification number |
Cai01.08.09.Ph.D.2021.Ma.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Malek Mohammed Mohsen Aziz |
| 245 10 - TITLE STATEMENT |
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| Title |
Study of the protective effects of an angiotensin II receptor blocker and L-carnitine on doxorubicin-induced cardiorenal toxicity in rats / |
| Statement of responsibility, etc. |
Malek Mohammed Mohsen Aziz ; Supervised Helmy Moawad Sayed Ahmed , May Ahmed Galal |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة التأثيرات الوقائية لأحد غالقات مستقبل الانجيوتنسين-2 وال-كارنيتين في سمية القلب والكُلى بفعل دوكسوروبيسين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Malek Mohammed Mohsen Aziz , |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
171 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background:Doxorubicin (DOX), an anthracycline antibiotic, is an important antineoplastic agent due to its high antitumor efficacy in haematological, as well as in solid malignancies. The clinical use of DOX is limited due to its cardiorenaltoxic side effects. Aim: The present study aimed to investigate the possible protective effect of olmesartan (Olm) or L-carnitine (L-CA) and their combination in cardiorenaltoxicity induced by Doxorubicin (DOX) in rats. Methods: Male albino rats were randomly divided into seven experimental groups (n=8): Group I: normal control, group II: L-CA, Group III: Olm, Group IV: DOX.The other three groups were treated with Olm, L-CA and their combination for 2 weeks, after induction of cardiorenaltoxicityby a single dose of DOX. On the last day of treatment, rats were anaesthetized with thiopental, then their echocardiograph (echo-c) was recorded and blood samples were collected to determine troponin I, creatine kinase-MB (CK-MB), lactate dehyclrogenase (LDH), creatinine (Cr), blood urea nitrogen (BUN) and kidney injury molecule-1 (KIM-1)in order to assess cardiac and renal functions. Furthermore, rats were sacrificed by cervical dislocation, and the heart and kidney were excised and homogenized to assess oxidative stress markers such as, reduced glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) in both tissues.The proposed possible anti-inflammatory effects were investigated through determination of tumor necrosis factor-alpha (TNF-Ü), intercellular adhesion molecules-1(ICAM-1), interleukin IL-1Ý (IL-1 Ý), myeloperoxidase (MPO), nuclear factor- kappa B (NF-kB) and transforming growth factor Beta (TGF-Ý), which has emerged as having a key role in the development of cardiorenal hypertrophy.Furthermore, Immunohistochemical staining of caspase-3 in both heart and kidney tissues was performed, as key marker of apoptosis. Finally, histopathologicalexaminationsof both heart and renal tissues wereperformed. Results:DOXshowed a significant elevation in serum troponin I, CK-MB, LDH and creatinine, BUN as well as KIM-1. Moreover, DOXshowed a significant increase in TNF-Ü, ICAM-1, IL-1, MPO, NF-kB and TGF-Ýin both cardiac and renal tissues. While, DOX showed a significant increase in MDA and decrease in SOD and GSH in both heart and renal tissuesOn the other hand, administration of L-CA and Olm attenuated DOX-evoked disturbances in the above mentioned parameters |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Cardiorenal toxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Doxorubicin |
| 653 #4 - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
L-carnitine |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Helmy Moawad Sayed Ahmed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
May Ahmed Galal , |
| Relator term |
|
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| Uniform Resource Identifier |
<a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
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| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
