MARC details
000 -LEADER |
fixed length control field |
03080cam a2200313 a 4500 |
003 - CONTROL NUMBER IDENTIFIER |
control field |
EG-GiCUC |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
210425s2020 ua dh f m 000 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
EG-GiCUC |
Language of cataloging |
eng |
Transcribing agency |
EG-GiCUC |
041 0# - LANGUAGE CODE |
Language code of text/sound track or separate title |
eng |
049 ## - LOCAL HOLDINGS (OCLC) |
Holding library |
Deposite |
097 ## - Thesis Degree |
Thesis Level |
Ph.D |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
Classification number |
Cai01.09.12.Ph.D.2020.Mo.E |
100 0# - MAIN ENTRY--PERSONAL NAME |
Personal name |
Mohamed Hamdy Sayed Mansy |
245 14 - TITLE STATEMENT |
Title |
The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin / |
Statement of responsibility, etc. |
Mohamed Hamdy Sayed Mansy ; Supervied Malak Mohamed Soliman , Rabab Tawfeek Mubarak |
246 15 - VARYING FORM OF TITLE |
Title proper/short title |
تأثير عامل نمو البشرة على الغدد اللعابية تحت الفكية فى الفئران البيضاء المزودة بعقار الدوكسوروبيسين |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Cairo : |
Name of publisher, distributor, etc. |
Mohamed Hamdy Sayed Mansy , |
Date of publication, distribution, etc. |
2020 |
300 ## - PHYSICAL DESCRIPTION |
Extent |
213 P. : |
Other physical details |
charts , facsimiles ; |
Dimensions |
25cm |
502 ## - DISSERTATION NOTE |
Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Epidermal growth factor (EGF) is a potent stimulant of proliferation and healing of the gastrointestinal tract. It is also acting as a cytoprotective agent that could stabilize cells against noxious agents. Doxorubicin (DXR) is widely used to treat different types of human neoplastic disease .Despite its high efficacy, the clinical application of doxorubicin was greatly restricted due to its multiple side effects. Since EGF exerts a potent growth and healing effect, it is supposed to play a role in the development and regeneration of salivary glands as well as oral mucosa. The present study was designed to investigate the effect of EGF injection on the cytotoxic effect of DXR induced in submandibular salivary gland of rats regarding the structure, ultrastructure, and immunohistochemical expression of VEGF and Ki-67. Sixty healthy adult male Albino rats, three months old and 200gm body weight were used in this study and were divided into three equal groups. Group I served as control group and the rats were received a single intraperitoneal injection of natural saline. In group II (DXR group), the rats received 20 mg/kg body weight DXR as a single intra peritoneal injection. Whereas , group III (DXR + EGF) was divided into two subgroups (A and B) .In group IIIA ,the rats received a single dose of DXR intraperitoneally (20 mg/kg body weight) and on the next day they were injected intraperitoneally with EGF in a daily dose of 10ug/kg body weight for 7 consecutive days. However, in group IIIB, the rats received the same intraperitoneal dose of DXR (20 mg/kg body weight) and 5 days later, they were injected with the same intraperitoneal dose of EGF (10ug/kg body weight) and for the same duration (7 consecutive days) |
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
Additional physical form available note |
Issued also as CD |
653 #4 - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Doxorubicin |
653 #4 - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Epidermal Growth Factor (EGF) |
653 #4 - INDEX TERM--UNCONTROLLED |
Uncontrolled term |
Submandibular salivary glands |
700 0# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Malak Mohamed Soliman , |
Relator term |
|
700 0# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Rabab Tawfeek Mubarak , |
Relator term |
|
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
Cataloger |
Nazla |
Reviser |
Revisor |
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
Cataloger |
Shimaa |
Reviser |
Cataloger |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |
Koha item type |
Thesis |