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The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin / (Record no. 80767)

MARC details
000 -LEADER
fixed length control field 03080cam a2200313 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210425s2020 ua dh f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.09.12.Ph.D.2020.Mo.E
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Mohamed Hamdy Sayed Mansy
245 14 - TITLE STATEMENT
Title The effect of epidermal growth factor on the submandibular salivary glands of albino rats receiving doxorubicin /
Statement of responsibility, etc. Mohamed Hamdy Sayed Mansy ; Supervied Malak Mohamed Soliman , Rabab Tawfeek Mubarak
246 15 - VARYING FORM OF TITLE
Title proper/short title تأثير عامل نمو البشرة على الغدد اللعابية تحت الفكية فى الفئران البيضاء المزودة بعقار الدوكسوروبيسين
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Mohamed Hamdy Sayed Mansy ,
Date of publication, distribution, etc. 2020
300 ## - PHYSICAL DESCRIPTION
Extent 213 P. :
Other physical details charts , facsimiles ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Biology
520 ## - SUMMARY, ETC.
Summary, etc. Epidermal growth factor (EGF) is a potent stimulant of proliferation and healing of the gastrointestinal tract. It is also acting as a cytoprotective agent that could stabilize cells against noxious agents. Doxorubicin (DXR) is widely used to treat different types of human neoplastic disease .Despite its high efficacy, the clinical application of doxorubicin was greatly restricted due to its multiple side effects. Since EGF exerts a potent growth and healing effect, it is supposed to play a role in the development and regeneration of salivary glands as well as oral mucosa. The present study was designed to investigate the effect of EGF injection on the cytotoxic effect of DXR induced in submandibular salivary gland of rats regarding the structure, ultrastructure, and immunohistochemical expression of VEGF and Ki-67. Sixty healthy adult male Albino rats, three months old and 200gm body weight were used in this study and were divided into three equal groups. Group I served as control group and the rats were received a single intraperitoneal injection of natural saline. In group II (DXR group), the rats received 20 mg/kg body weight DXR as a single intra peritoneal injection. Whereas , group III (DXR + EGF) was divided into two subgroups (A and B) .In group IIIA ,the rats received a single dose of DXR intraperitoneally (20 mg/kg body weight) and on the next day they were injected intraperitoneally with EGF in a daily dose of 10ug/kg body weight for 7 consecutive days. However, in group IIIB, the rats received the same intraperitoneal dose of DXR (20 mg/kg body weight) and 5 days later, they were injected with the same intraperitoneal dose of EGF (10ug/kg body weight) and for the same duration (7 consecutive days)
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Doxorubicin
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Epidermal Growth Factor (EGF)
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Submandibular salivary glands
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Malak Mohamed Soliman ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Rabab Tawfeek Mubarak ,
Relator term
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Shimaa
Reviser Cataloger
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.09.12.Ph.D.2020.Mo.E 01010110083339000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.09.12.Ph.D.2020.Mo.E 01020110083339000 22.09.2023 CD - Rom 83339.CD