Pharmaceutical studies on transdermal delivery of a certain cholesterol lowering drug / (Record no. 80913)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02913cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210517s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2021.Ya.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yasmin Ahmed Eltellawy |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmaceutical studies on transdermal delivery of a certain cholesterol lowering drug / |
| Statement of responsibility, etc. | Yasmin Ahmed Eltellawy ; Supervised Salwa Mohamed Salah , Dalia Samuel Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات صيدلية عن توصيل عقار مثبط للكوليسترول عبر الجلد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yasmin Ahmed Eltellawy , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 129 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Atorvastatin calcium (ATC) is an HMG-CoA reductase inhibitor, efficiently exerting its action by competitively inhibiting the HMG-CoA reductase enzyme, interfering with cholesterogenesis in the liver. It also decreases the level of LDL by increasing its reuptake and degradation. Additionally, it has been shown to decrease the progression of coronary atherosclerosis, by shrinking the lipid core of the plaque. The main drawback of oral ATC is its limited bioavailability of 12 - 14%, this is attributed to pre-systemic gastrointestinal clearance and extensive hepatic first-pass metabolism. In order to overcome this poor bioavailability, ATC is administered in high doses which results in patients being susceptible to more serious adverse effects including; arthralgia, severe muscle toxicity such as rhabdomyolysis, liver abnormalities and might lead to kidney failure. Hence the present study aims to develop ATC transdermal proniosomes to allow drug to penetrate the skin avoiding portal circulation, possessing its anti-hyperlipidemic effect ameliorating its orally induced hepatotoxicity.The ATC loaded proniosomal gels were prepared for transdermal delivery, characterized and evaluated regarding in vitro physicochemical properties, ex vivo skin permeation, and in vivo performance in terms of anti-hyperlipidemic efficacy and ATC safety profile regarding hepatocellular damage. From literature, only few reports investigated the transdermal delivery of ATC from proniosomesز To the best of our knowledge, there was no previous investigation made to fully explore transdermal proniosomal ATC pharmacodynamic efficacy along with its ability to ameliorate the drug side effects specially liver toxicity commonly associated with statins |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Atorvastatin calcium |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hyperlipidemia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Proniosomes |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Samuel Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Salwa Mohamed Salah , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2021.Ya.P | 01010110083427000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2021.Ya.P | 01020110083427000 | 22.09.2023 | CD - Rom | 83427.CD |