Different nanovesicular carriers for enhanced topical delivery for a certain drug model / (Record no. 80975)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03026cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210522s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2021.Sh.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shaimaa Mosallam Mohammed Elsaid |
| 245 10 - TITLE STATEMENT | |
| Title | Different nanovesicular carriers for enhanced topical delivery for a certain drug model / |
| Statement of responsibility, etc. | Shaimaa Mosallam Mohammed Elsaid ; Supervised Ahmed Hassen Elshafeey , Aly Ahmed Abdelbary |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | إستخدام الحويصلات النانومترية المختلفة كحوامل لتحسين الفاعلية السطحية لنموذج عقار معين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Shaimaa Mosallam Mohammed Elsaid , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 125 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Fungal infections are one of the most commonly encountered diseases affecting the skin. Treatment approaches include both topical and systemic antifungal agents. Antifungal agents used topically are generally preferred due to drawbacks encountered with the conventional systemic treatment; including specific organic toxicity, interaction with other therapeutic agents and an increase in the cost of treatment. Since the therapeutic efficacy of a locally applied drug depends mainly on its ability to penetrate and permeate the skin, Conventional formulations are slowly becoming outdated and replaced by other novel carriers that are able to overcome the skin barrier. Vesicular systems are among the promising delivery systems to achieve the topical delivery of antifungal agents.Terconazole (TCZ) is a new broad-spectrum topical antifungal agent that belongs to the triazole class of drugs and is used mainly in the treatment of vulvovaginal candidiasis. It shows better mycological and clinical cure rates in comparison with other imidazole antifungal agents in the treatment of fungal infections.TCZ acts by inhibition of the fungal cytochrome P-450 dependent 14a-demethylase.Thereby, the composition of sterol is changed.The clinical use of TCZ is limited because of its poor permeability characters. Based on the aspects of both drug and disease consideration, several nanocarriers (NC) were developed to select the most promising carrier for successful drug delivery. However, the skin is one of the tightest barriers of the human body due to the presence of stratum corneum (SC). SC, the uppermost layer of the skin, is hygroscopic impermeable to water and behaves as the rate-limiting step for drugs' diffusion across the skin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nanovesicular carriers |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Stratum corneum (SC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Terconazole (TCZ) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Hassen Elshafeey , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aly Ahmed Abdelbary , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2021.Sh.D | 01010110083481000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2021.Sh.D | 01020110083481000 | 22.09.2023 | CD - Rom | 83481.CD |