A pharmaceutical study on local corticosteroid drug delivery systems for the treatment of oral ulcerative lesions / (Record no. 81128)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03403cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210531s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.Ph.D.2021.We.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Wedian Younis Abdelgawad |
| 245 12 - TITLE STATEMENT | |
| Title | A pharmaceutical study on local corticosteroid drug delivery systems for the treatment of oral ulcerative lesions / |
| Statement of responsibility, etc. | Wedian Younis Abdelgawad ; Supervised Magdy Ibrahim Mohamed , Mary Kamal Gad |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة صيدلية عن نظم التوصيل الدوائى الموضعى لأحد الكورتيكوستيرويدات لعلاج افات تقرحات الفم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Wedian Younis Abdelgawad , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 258 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | An ideal locally applied pharmaceutical dosage form should release the drug in a controlled manner as well as remain available at the administration site with an effective concentration. Proniosomes are non-ionic based surfactant vesicles that can be transformed into niosomes upon simple hydration. Proniosomes possess many advantages such as, avoidance of physical instabilities, prevention of chemical stability problems, sterilization simplicity and easy storage conditions. In addition to the above advantages, they show a controlled, targeted and sustained manner of release. For drugs delivered to the oral mucosa, it is essential to consider two significant factors; extending contact time between formula and mucosa as well as the lower permeability to large molecules.The capability of the delivery system to be retained at a specific site for a prolonged time gives a good chance for local treatment as well as systemic drug management.Oral ulcerative lesions are a group of ulcers distinguished by an erosion of the epithelium, underlying connective tissue, or both. Such lesions can be resulted from different reasons, traumatic etiology (physical or chemical), infections (viral, bacterial or fungal), idiopathic and malignancy.Local corticosteroid drugs are commonly used in the management of different oral ulcerative lesions to reduce pain and inflammation.Their capacity to adjust aggravation and resistant reaction are due to their ability to balance out the lysosomal membrane and reducing the lymphocytic exudates.Fluticasone Propionate (FP) is considered as one of the potent corticosteroid drugs. Its potency, optimized topical activity, lower oral systemic bioavailability and lower mineralocorticoid activity in comparison to other corticosteroids make it the excellent choice for the management of variable oral ulcerative lesions. Therefore, the aim of our current work was to design and evaluate smart drug delivery systems for localized controlled release of the potent corticosteroid, FP for the local treatment of oral ulcerative lesions assuring safety, efficacy and minimum systemic side effects |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Corticosteroid |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Drug delivery systems |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oral ulcerative lesions |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ibrahim Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mary Kamal Gad , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.Ph.D.2021.We.P | 01010110083558000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.Ph.D.2021.We.P | 01020110083558000 | 22.09.2023 | CD - Rom | 83558.CD |