The expression of the apoptosis-regulating mirnas 16 and 21 in oral squamous cell carcinoma : (Record no. 81258)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03159cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032748.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210612s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.09.14.Ph.D.2020.He.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hebatollah Khaled Rizk |
| 245 14 - TITLE STATEMENT | |
| Title | The expression of the apoptosis-regulating mirnas 16 and 21 in oral squamous cell carcinoma : |
| Remainder of title | In vitro study / |
| Statement of responsibility, etc. | Hebatollah Khaled Rizk ; Supervised Naglaa Mohamed Elhosary , Safa Fathy Abdelghani , Olfat Shaker |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى سرطان الخلايا الحرشفيه بالفم (miRNA 16,21 )التعبير الجينى لمنظمى موت الخلايا المبرمج : |
| Remainder of title | دراسه معمليه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hebatollah Khaled Rizk , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 115 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral and Maxillofacial Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: to examine whether the expression of miRNA-16 and 21 (which are considered as apoptosis regulating miRNAs) alters in oral squamous cell carcinoma (OSCC) versus normal oral epithelium, and correlate their expression levels with that of one of their common downstream targets (the antiapoptotic BCL-2 protein). Methodology: this study was conducted on a total of 32 OSCC cases and 16 normal epithelium control cases. OSCC cases were graded as well, moderately, or poorly differentiated SCC, based on the degree of differentiation, cellular pleomorphism, and mitotic activity. Both moderately and poorly differentiated cases were placed as one group, whereas well differentiated cases were placed as a separate group. Quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate the expression of miRNA-16 and miRNA-21 in the 3 studied groups. The expression of BCL2 protein was evaluated by Immunohistochemical staining. Results: there was a statistically significant difference in miRNA-16 expression among the 3 studied groups, where it decreased gradually from the normal control group (mean 0.93) , followed by the well differentiated OSCC group (mean 0.36) , reaching the least levels in the moderate/poorly differentiated group (mean 0.17) . Also, the 3 groups showed a statistically significant difference in miRNA-21 expression, where the highest levels were observed in the moderate/poorly differentiated OSCC group (mean 9.35), followed by the well differentiated group (mean 3.70), and finally the normal control group (mean 0.96). However, all the studied groups showed negative BCL-2 immunostaining |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oral squamous cell carcinoma (OSCC) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymerase chain reaction (qRT-PCR) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | The apoptosis-regulating mirnas 16 and 21 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Mohamed Elhosary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Safa Fathy Abdelghani , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.09.14.Ph.D.2020.He.E | 01010110083652000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.09.14.Ph.D.2020.He.E | 01020110083652000 | 22.09.2023 | CD - Rom | 83652.CD |