Expression profiles of circular PTPN22, microRNA-200a-3p and interleukin-2 in systemic lupus erythematosus shock / (Record no. 81314)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03191cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032750.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210616s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.19.Ph.D.2021.Ha.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hagar Lotfy Abdelbaky Ahmad Mowafy |
| 245 10 - TITLE STATEMENT | |
| Title | Expression profiles of circular PTPN22, microRNA-200a-3p and interleukin-2 in systemic lupus erythematosus shock / |
| Statement of responsibility, etc. | Hagar Lotfy Abdelbaky Ahmad Mowafy ; Supervised Kamal Maurice Hanna , Lamiaa Abdelfattah Madkour, Maha Mahmoud Kotb |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | والانترلوكين فى الذئبة الحمراء a200-3pوالحمض النووى الريبوزى المصغر circPTPN22قياس التعبير الجينى للحمض النووى الريبوزى الدائرى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hagar Lotfy Abdelbaky Ahmad Mowafy , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 121 P . : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by production of a variety of autoantibodies and various organs damage. Circular RNAs (circRNAs) are novel class of endogenous noncoding RNAs (ncRNAs) which have been involved in the development of various diseases. However, there is little knowledge about their associations with SLE. The aim of our study was to compare the plasma expression levels of circPTPN22, miR-200a-3p and IL-2 in SLE patients with that of healthy controls. The study was conducted on 45 SLE patients and 45 healthy individuals who served as the control group. The expression levels of circPTPN22 and miR-200a-3p were evaluated in the plasma of both groups by real time reverse transcription -polymerase chain reaction (RT-PCR). while plasma levels of IL-2 were determined using the enzyme-linked immunosorbent assay (ELISA) technique. SLE patients showed significantly lower plasma expression levels of circPTPN22 (P < 0.001), higher plasma expression levels of miR-200a-3p (P < 0.001) and lower plasma IL-2 levels (P < 0.001) compared to the control group. There was a statistically significant negative correlation between the expression levels of circPTPN22 and miR-200a-3p in the plasma of SLE patients (r = -0.567, P = < 0.001). However, no correlation was detected between the expression levels IL-2 and each of circPTPN22 (r = 0.170, P = 0.265) and miR-200a-3p (r = -0.284, P = 0.059). CircPTPN22, miR-200a-3p and IL-2 are potential non-invasive biomarkers in SLE diagnosis and potential therapeutic targets. Further studies are required to investigate the role of circPTPN22 and miR-200a-3p in the pathogenesis of SLE |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | circPTPN22 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CircRNAs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | IL-2 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamal Maurice Hanna , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Abdelfattah Madkour, |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Mahmoud Kotb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.19.Ph.D.2021.Ha.E | 01010110083683000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.19.Ph.D.2021.Ha.E | 01020110083683000 | 22.09.2023 | CD - Rom | 83683.CD |