Dickkopf-1 (DKK1), Midkine (MDK), and Golgi-protein 73 (GP73) as predictor markers of Hepatocellular carcinoma in comparison with Ü-Fetoprotein (AFP) in chronic Hepatitis C virus patients / (Record no. 81336)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02645cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210619s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.05.Ph.D.2020.Ra.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rania Ahmed Talaat Abdelzaher |
| 245 10 - TITLE STATEMENT | |
| Title | Dickkopf-1 (DKK1), Midkine (MDK), and Golgi-protein 73 (GP73) as predictor markers of Hepatocellular carcinoma in comparison with Ü-Fetoprotein (AFP) in chronic Hepatitis C virus patients / |
| Statement of responsibility, etc. | Rania Ahmed Talaat Abdelzaher ; Supervised Elsayed Tarek Abdelsalam , Abdelrahman Nabwy Zekri , Mohamed Mahmoud Zakaria Elkassas |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى المرضى ذوى الاصابه المزمنه بفيروس ج (HCC)بالمقارنة ببروتين الفافيتوبروتين كدلالات للكشف المبكر عن الاورام السرطانيه الكبديه (GP73)وبروتين جولوجى ٧٣(MDK )ميديكين(DKK1)تقدير كل من البروتينات ديكوف- ١ |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Rania Ahmed Talaat Abdelzaher , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 152 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Hepatocellular carcinoma (HCC) is the second most common cause of cancer related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. In the current study we assessed the expression levels of Golgi protein 73 (GP73), Midkine (MDK) and Dickkopf-1(DKK-1) proteins separately and in combination at different stages of hepatocarcinogenesis. The ROC curve analysis for the studied markers showed (1) 88.5% sensitivity, 80.6% specificity, 69% PPV , 93.5% NPV and (AUC 0.91) for MDK; (2) 93.6%, 86.9%, 77.7%, 96.5% for DKK-1. (3) 91%, 85%, 74.7%, 95% (AUC 0.96) for GP73, and (4) 74.4%, 84.4%, 69.9%, 87.1% (AUC 0.81) for AFP. Serum levels of GP73, MDK, and DKK-1 are comparable to AFP as diagnostic biomarkers for early detection of HCC patients from Egypt. A two markers panel including Gp73 and DKK-1 showed the highest specificity and sensitivity among different markers combinations |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Golgi-protein 73 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatocellular carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Midkine, Dickkopf-1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelrahman Nabwy Zekri , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elsayed Tarek Abdelsalam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mahmoud Zakaria Elkassas , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.05.Ph.D.2020.Ra.D | 01010110083704000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.05.Ph.D.2020.Ra.D | 01020110083704000 | 22.09.2023 | CD - Rom | 83704.CD |