Expression of NKp30 in de novo acute myeloid leukemia patients and its Impact on prognosis / (Record no. 81381)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03064cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032752.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210624s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2021.Ya.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Yasmin Mohsen Abdelrazek Mohamed |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of NKp30 in de novo acute myeloid leukemia patients and its Impact on prognosis / |
| Statement of responsibility, etc. | Yasmin Mohsen Abdelrazek Mohamed ; Supervised Dina Mohamed Rasheed Bahgat , Maha Saleh Madbouly Ibrahim , Aliaa Sayed Eldash |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى مرض سرطان الدم النخاعى الحاد حديثى التشخيص و تاثيره على تطور المرض NKp30دور تعبيرالمستقبلات المناعية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Yasmin Mohsen Abdelrazek Mohamed , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 150 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by uncontrolled proliferation of hematopoietic progenitor cells with arrest of maturation and disruption of normal hematopoiesis. NKp30 is a protein found on the surface of human natural killer (NK) cells. The ligand of NKp30 is called B7-H6. NKp30 belongs to a group of molecules called Natural Cytotoxicity Receptors (NCRs). When NKp30 on a NK cell binds to B7-H6 on a human tumor cell, the NK cell is triggered to become cytotoxic and exert antitumor effects. We studied the expression of NKp30 on 35 patients diagnosed with AML and 30 controls, to evaluate the impact of its expression on outcome and its possible association with other known prognostic markers. Flowcytometric analysis was performed using direct staining method by monoclonal antibody CD337 (NKp30) gated on NK cells (CD3-/56+).The expression of NKp30 on NK cells was found to be significantly lower in AML group compared to the control group, with p-value 0.042 for the NKp30% and p-value <0.001 for the rMFI. ROC analysis was used to predict cut off values for NKp30 expression as a marker for stratifying AML patients. NKp30% expression cut off was chosen at 11.155%. rMFI expression cut off was chosen at 4.13, with sensitivity (62.9% , 85.7%) and specificity (53.3% ,66.7%) respectively. Nkp30% significantly correlated with overall survival (P=0.030); where patients with high expression of NKp30% had longer OS time while patients with low expression of NKp30 % were more prone to earlier death than those with high marker expression (HR:2.580) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | AML |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | NKp30 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Overall survival |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aliaa Sayed Eldash , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Mohamed Rasheed Bahgat , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Saleh Madbouly Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2021.Ya.E | 01010110083747000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2021.Ya.E | 01020110083747000 | 22.09.2023 | CD - Rom | 83747.CD |