Osteoprotegerin and Osteoprotegerin ligand serum levels and bone health in Ý -Thalassemia patients / (Record no. 81382)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02850cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032752.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210624s2021 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.28.M.Sc.2021.Ma.O |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Rabea Ahmed Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Osteoprotegerin and Osteoprotegerin ligand serum levels and bone health in Ý -Thalassemia patients / |
| Statement of responsibility, etc. | Marwa Rabea Ahmed Hassan ; Supervised Ilham Youssry Mohamed Ibrahim , Rania Mohamed Samy , Dalia Salaheldin Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | مستويات الاوستوبروتيجيرين و رابط الاوستوبروتيجيرين فى مصل الدم وصحه العظام فى مرضى الثلاسميا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Rabea Ahmed Hassan , |
| Date of publication, distribution, etc. | 2021 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 P . : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Osteoporosis is a notable cause of morbidity in thalassemia major (TM) patients with a complex pathophysiology and multifactorial etiology. Osteoprotegerin (OPG) and osteoprotegerin ligand (OPGL) have been recently implicated in the pathogenesis of osteoporosis. Aims: To measure the level of OPG and OPGL serum levels in patients with Ý thalassemia and to evaluate the relation between the OPG&OPGL level and the bone mineral density (BMD) in children with Thalassemia Major. Patients and methods: In 60 Egyptian thalassemic patients and 60 healthy control children (age = 5-14 year), serum OPG and serum OPGL measured by ELIZA. The patients had recent results of BMD scanning using dual X-ray absorptiometry (DEXA).Results: High prevalence of bone diseases was detected in TM patients, 40% had spine low bone mass, 10% had femur low bone mass, 70% complained from bone pain and 21.7% had history of fracture of long bone. The thalassemic patients showed significantly lower serum levels of OPG (P=0.003) and lower serum levels of OPGL (P=0.002) OPG/ OPGL ratio (P=0.019) as compared with controls. We couldn{u2019}t demonstrate significant association between serum OPG & serum OPGL levels and BMD.Conclusions: Our data underline the important role of the OPG {u2013} OPGL system in the pathogenesis of osteoporosis in thalassemia major, which could be a potential target for novel therapeutic agents |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoprotegerin (OPG) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thalassemia major (TM) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Salaheldin Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ilham Youssry Mohamed Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohamed Samy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.28.M.Sc.2021.Ma.O | 01010110083748000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.28.M.Sc.2021.Ma.O | 01020110083748000 | 22.09.2023 | CD - Rom | 83748.CD |