MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03093cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210630s2021 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.04.Ph.D.2021.No.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Noha Ryad Mohamed Mohamed Gabr |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Design and synthesis of certain new pyridine, pyrimidine and benzimidazole containing compounds with cytotoxic activity / |
| Statement of responsibility, etc. |
Noha Ryad Mohamed Mohamed Gabr ; Supervised Mohamed Mohsen Ismail , Salwa Elsayed Mohamed Elmeligie , Mohammed Kamal Abdelhamid |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تصميم وتشييد بعض المركبات الجديدة المحتوية على البيريدين: البيريميدين والبنزاميدازول ذات النشاط السام للخلايا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Noha Ryad Mohamed Mohamed Gabr, |
| Date of publication, distribution, etc. |
2021 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
90 P . : |
| Other physical details |
charts , facsmilies ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The present thesis composed of five chapters in which a new series of pyridine, pyrimidine and benzimidazole derivatives was designed and synthesized as potential antitumor molecules. The first chapter is an introduction which consists of a brief survey on the different methods of synthesis of pyridine, pyrimidine and benzimidazole derivatives and some of their useful biological activities. The second chapter explains the aim of the work and Schemes that have been carried out to obtain the new target pyridine, pyrimidine and benzimidazole derivatives The third chapter clarifies the theoretical discussion of the experimental work that has been carried out for the preparation of the target compounds IVa-XIXa-c as well as discussion of their spectral data. Additionally, a brief account on the docking study that explained the biological results through the binding conformations of the new compounds in comparison with the lead. The fourth chapter represents the experimental part of this work, which contains the detailed procedures used for the synthesis of the starting materials and the target pyridine and pyrimidine derivatives IVa-VIa-d as well as benzimidazole derivatives IXXIXa- c. Moreover, this chapter includes detailed spectral analysis, physical properties as well as elemental analysis of these compounds. It has been also shed the light on the cytotoxic activities of the newly synthesized pyridine and pyrimidine derivatives IVa-VIa-d in comparison with combretastatin-A-4 (CA-4) as a standard cytotoxic agent and benzimidazole derivatives IXa-XIXa-c in comparison with campetothecin (CPT)as a standard cytotoxic agent |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Leukemia |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyridine |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyrimidine benzimidazole |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Mohsen Ismail , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohammed Kamal Abdelhamid , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Salwa Elsayed Mohamed Elmeligie , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Amira |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
